Aro A, Pietinen P, Uusitalo U, Tuomilehto J
Department of Biochemistry, National Public Health Institute, Helsinki, Finland.
J Intern Med. 1989 Aug;226(2):127-32. doi: 10.1111/j.1365-2796.1989.tb01367.x.
The association between the consumption of coffee and tea and serum cholesterol concentration was studied in a population sample of 653 men and 695 women from east and south-west Finland. Cholesterol and high density lipoprotein (HDL) cholesterol were determined from fresh serum samples. Smoking and the intake of coffee, tea and alcohol were assessed by a questionnaire, and nutrient intake was determined from 3-day food records. Serum cholesterol and non-HDL cholesterol showed a positive and linear association with coffee consumption in men. In women, no such significant linear association was evident, although the highest mean serum cholesterol levels were found in subjects consuming seven to nine cups of coffee daily. Both in men and in women coffee consumption was positively associated with smoking and the intake of saturated and monounsaturated fatty acids and cholesterol. Serum cholesterol values, adjusted for age, body mass index, smoking, dietary cholesterol, fatty acids, alcohol and physical activity, showed a significant linear association with coffee consumption in men but not in women. Although coffee consumption and high intake of saturated fatty acids and cholesterol were related both in men and in women, adjustment for dietary and other confounding factors did not remove the association between coffee consumption and serum cholesterol concentration in men.
在芬兰东部和西南部的653名男性和695名女性人群样本中,研究了咖啡和茶的摄入量与血清胆固醇浓度之间的关联。从新鲜血清样本中测定胆固醇和高密度脂蛋白(HDL)胆固醇。通过问卷调查评估吸烟情况以及咖啡、茶和酒精的摄入量,并根据3天的饮食记录确定营养摄入量。男性的血清胆固醇和非HDL胆固醇与咖啡摄入量呈正线性关联。在女性中,虽然每天饮用7至9杯咖啡的受试者血清胆固醇平均水平最高,但未发现明显的这种显著线性关联。男性和女性的咖啡摄入量均与吸烟以及饱和脂肪酸、单不饱和脂肪酸和胆固醇的摄入量呈正相关。在对年龄、体重指数、吸烟、膳食胆固醇、脂肪酸、酒精和身体活动进行调整后,男性的血清胆固醇值与咖啡摄入量呈显著线性关联,而女性则不然。虽然男性和女性的咖啡摄入量与饱和脂肪酸和胆固醇的高摄入量均有关联,但调整饮食和其他混杂因素并未消除男性咖啡摄入量与血清胆固醇浓度之间的关联。