[The diagnostic importance of low-density lipoprotein (LP-X) for the diagnosis of cholestasis].

Based on the clinical, biochemical and morphological examination of a selected group of patients, the following may be said about low-density lipoprotein (LP-X): The LP-X test 1. proves to be a reliable method of examination for diagnosing cholestasis. It is a quick and simple test; 2. has a highly significant statistical relationship (x2 = 31,7) to the histological results and other parameters indicating cholestasis; 3. does not, however, distinguish between intra- and extrahepatic cholestasis and positive results do not allow any conclusion as to the etiology of the icterus; 4. makes it possible to diagnose cases of cholestasis with aP activities not clinically manifest; 5. in borderline cases conclusions may be drawn from a combination of LP-X and aP results and, most of all, from LP-X and gamma-GT, a highly sensitive, specific and simple method of diagnosis. 6. diagnostic findings of still greater significance resulting from applying laboratory data indicating or precluding cholestasis may be derived from a prospective study with a larger group of patients, using the same parameters and taking the likelihood ratio into consideration.