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对位于大肠杆菌K-12的IS3元件α3β3和β5α5内的倒位末端进行核苷酸序列分析。

Nucleotide sequence analysis of the inversion termini located within IS3 elements alpha 3 beta 3 and beta 5 alpha 5 of Escherichia coli K-12.

作者信息

Ajdic D, Jovanovic G, Glisin V, Hejna J, Savic D J

机构信息

Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia.

出版信息

J Bacteriol. 1991 Jan;173(2):906-9. doi: 10.1128/jb.173.2.906-909.1991.

DOI:10.1128/jb.173.2.906-909.1991
PMID:1846154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC207089/
Abstract

This paper presents the first detailed structural analysis of termini of an inversion mediated by recombination between Escherichia coli native IS elements. The complete nucleotide sequence of the inversion termini in the lactose region of Escherichia coli K-12 confirms our previous suggestion that the inversion occurred by homologous recombination between alpha 3 beta 3 and beta 5 alpha 5 IS3 elements (D. J. Savic, J. Bacteriol. 140:311-319, 1979; D. J. Savic, S. Romac, and S. D. Ehrlich, J. Bacteriol. 155:943-946, 1983). The data show a slight structural divergence of alpha 3 beta 3 and beta 5 alpha 5 elements, but they do not reveal new sequences within recombined IS3 elements that could influence the expression of nearby genes.

摘要

本文首次详细分析了由大肠杆菌天然插入序列（IS）之间的重组介导的倒位末端结构。大肠杆菌K-12乳糖区域倒位末端的完整核苷酸序列证实了我们之前的推测，即该倒位是由α3β3和β5α5 IS3元件之间的同源重组发生的（D. J. Savic，《细菌学杂志》140:311 - 319，1979；D. J. Savic，S. Romac，和S. D. Ehrlich，《细菌学杂志》155:943 - 946，1983）。数据显示α3β3和β5α5元件存在轻微的结构差异，但未揭示重组IS3元件内可能影响附近基因表达的新序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d9/207089/83556b5ad3f0/jbacter00092-0501-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d9/207089/83556b5ad3f0/jbacter00092-0501-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48d9/207089/83556b5ad3f0/jbacter00092-0501-a.jpg

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1
Nucleotide sequence analysis of the inversion termini located within IS3 elements alpha 3 beta 3 and beta 5 alpha 5 of Escherichia coli K-12.对位于大肠杆菌K-12的IS3元件α3β3和β5α5内的倒位末端进行核苷酸序列分析。
J Bacteriol. 1991 Jan;173(2):906-9. doi: 10.1128/jb.173.2.906-909.1991.
2
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本文引用的文献

1
Inversion in the lactose region of Escherichia coli K-12: inversion termini map within IS3 elements alpha 3 beta 3 and beta 5 alpha 5.大肠杆菌K-12乳糖区域的倒位：倒位末端定位在IS3元件α3β3和β5α5内。
J Bacteriol. 1983 Aug;155(2):943-6. doi: 10.1128/jb.155.2.943-946.1983.
2
IS3 can function as a mobile promoter in E. coli.IS3在大肠杆菌中可作为移动启动子发挥作用。
Nucleic Acids Res. 1982 Oct 11;10(19):5935-48. doi: 10.1093/nar/10.19.5935.
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A small cosmid for efficient cloning of large DNA fragments.一种用于高效克隆大片段DNA的小型黏粒。
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Comparison between the chromosomal maps of Escherichia coli and Salmonella typhimurium. Length of the inverted segment in the trp region.大肠杆菌和鼠伤寒沙门氏菌染色体图谱的比较。色氨酸区域中反向片段的长度。
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Evidence for the control by exrA and polA genes of two branches of the uvr gene-dependent excision repair pathway in Escherichia coli K-12.关于大肠杆菌K-12中uvr基因依赖性切除修复途径的两个分支受exrA和polA基因调控的证据。
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Cell. 1988 Jun 3;53(5):679-86. doi: 10.1016/0092-8674(88)90086-4.
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Proc Natl Acad Sci U S A. 1988 Dec;85(24):9391-5. doi: 10.1073/pnas.85.24.9391.
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Rearrangement of the bacterial chromosome: forbidden inversions.
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