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采用可逆加成-断裂链转移聚合法合成的恩诺沙星印迹整体柱。

Enrofloxacin-imprinted monolithic columns synthesized using reversible addition-fragmentation chain transfer polymerization.

作者信息

Liu Huina, Zhuang Xiaolei, Turson Mamat, Zhang Min, Dong Xiangchao

机构信息

College of Chemistry, Nankai University, Tianjin, China.

出版信息

J Sep Sci. 2008 Jun;31(10):1694-701. doi: 10.1002/jssc.200700602.

Abstract

Molecularly imprinted monolithic columns for selective separation of enrofloxacin were prepared by Reversible Addition-Fragmentation Chain Transfer (RAFT)-mediated radical polymerization. Different ratios of initiation system were used in the synthesis. The structures of the monoliths were characterized to study the relationship between the synthetic conditions and morphology of the monolithic material. The separation performance of the monoliths was evaluated by liquid chromatography. Under optimized synthetic conditions, a monolithic molecularly imprinted polymer (MIP) with high selectivity and improved column efficiency was obtained. The research has shown that RAFT polymerization provides more adjustable conditions for making monolithic materials with different morphologies. The results also demonstrated that homogeneous macro-pore size distribution and large specific surface area are the key factors providing good separation ability and column efficiency for MIP monolithic structures.

摘要

通过可逆加成-断裂链转移(RAFT)介导的自由基聚合制备了用于选择性分离恩诺沙星的分子印迹整体柱。在合成过程中使用了不同比例的引发体系。对整体柱的结构进行了表征,以研究合成条件与整体材料形态之间的关系。通过液相色谱法评估了整体柱的分离性能。在优化的合成条件下,获得了具有高选择性和改进柱效的整体分子印迹聚合物(MIP)。研究表明,RAFT聚合为制备具有不同形态的整体材料提供了更可调节的条件。结果还表明,均匀的大孔尺寸分布和大比表面积是为MIP整体结构提供良好分离能力和柱效的关键因素。

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