通过赫克根醇乙酸酯的还原和氧化官能化合成 14',15'-脱氢里特嗪 Y。
Synthesis of 14',15'-dehydro-ritterazine Y via reductive and oxidative functionalizations of hecogenin acetate.
机构信息
The Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA.
出版信息
Steroids. 2013 Feb;78(2):304-11. doi: 10.1016/j.steroids.2012.10.021. Epub 2012 Dec 10.
Abstract
An analog of ritterazine Y was synthesized from hecogenin acetate in 23 steps via functional group manipulations of hecogenin acetate. Preparation of the north G and south Y units and the late stage Guo-Fuchs asymmetric coupling of the both units afforded the ritterazine Y analog.
摘要
从海柯吉宁乙酸酯出发，经 23 步反应，通过海柯吉宁乙酸酯的官能团操作，合成了里特灵 Y 的类似物。北 G 和南 Y 单元的制备以及两个单元的后期 Guo-Fuchs 不对称偶联提供了里特灵 Y 类似物。
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