Tissue-engineered heart valve prostheses: 'state of the heart'.

作者信息

Migneco Francesco, Hollister Scott J, Birla Ravi K

机构信息

Section of Cardiac Surgery, the University of Michigan, B560 Medical Science Research Building II, 1150 West Medical Center Drive, Ann Arbor, MI 48109-2110, USA.

出版信息

Regen Med. 2008 May;3(3):399-419. doi: 10.2217/17460751.3.3.399.

DOI:10.2217/17460751.3.3.399

PMID:18462061

Abstract

In this article, we will review the current state of the art in heart valve tissue engineering. We provide an overview of mechanical and biological replacement options, outlining advantages and limitations of each option. Tissue engineering, as a field, is introduced, and specific aspects of valve tissue engineering are discussed (e.g., biomaterials, cells and bioreactors). Technological hurdles, which need to be overcome for advancement of the field, are also discussed.

摘要