Gil Salvador, Parra Margarita, Rodríguez Pablo
Department de Organic Chemistry, Universitat de València, Dr. Moliner 50, 46100 Burjassot, Spain.
Molecules. 2008 Mar 27;13(4):716-28. doi: 10.3390/molecules13040716.
Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding gamma-cyanoacids, which on hydrogenation yielded gamma-amino acids. This two step methodology improves upon previously described results. Poor e.e's resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amide induction.
向溴乙腈中加入羧酸二阴离子，可高产率地得到相应的γ-氰基酸，γ-氰基酸经氢化可得到γ-氨基酸。这种两步法比先前描述的结果有所改进。我们试图通过手性酰胺诱导来驱动这种转化的对映选择性，但得到的对映体过量值较低。
