大规模生物技术生产抗白血病海洋天然产物索比西拉酮 A。

Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A.

机构信息

Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany.

出版信息

Mar Drugs. 2007 Jun 25;5(2):23-30. doi: 10.3390/md502023.

DOI:10.3390/md502023

PMID:18463724

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2365691/

Abstract

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.

摘要

在从海绵源微生物中寻找新型生物活性化合物的过程中，我们最近鉴定出两种结构和生物合成上都前所未有的真菌代谢产物，新型生物碱 sorbicillactone A 和 sorbicillactone B。Sorbicillactone A 对白血病细胞具有活性，而没有明显的细胞毒性。因此，我们开发了一种有效的生物技术生产方法，并进行了大规模的分离，为正在进行的临床前研究和结构-活性关系（SAR）研究提供了足够的材料。