Wali Adil Farooq, Majid Sabhiya, Rasool Shabhat, Shehada Samar Bassam, Abdulkareem Shahad Khalid, Firdous Aimen, Beigh Saba, Shakeel Sheeba, Mushtaq Saima, Akbar Imra, Madhkali Hassan, Rehman Muneeb U
RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
Department of Biochemistry, Govt. Medical College (GMC), Karan Nagar, Srinagar 190010, J&K, India.
Saudi Pharm J. 2019 Sep;27(6):767-777. doi: 10.1016/j.jsps.2019.04.013. Epub 2019 Apr 24.
Marine natural products have as of now been acknowledged as the most important source of bioactive substances and drug leads. Marine flora and fauna, such as algae, bacteria, sponges, fungi, seaweeds, corals, diatoms, ascidian etc. are important resources from oceans, accounting for more than 90% of the total oceanic biomass. They are taxonomically different with huge productive and are pharmacologically active novel chemical signatures and bid a tremendous opportunity for discovery of new anti-cancer molecules. The water bodies a rich source of potent molecules which improve existence suitability and serve as chemical shield against microbes and little or huge creatures. These molecules have exhibited a range of biological properties antioxidant, antibacterial, antitumour etc. In spite of huge resources enriched with exciting chemicals, the marine floras and faunas are largely unexplored for their anticancer properties. In recent past, numerous marine anticancer compounds have been isolated, characterized, identified and are under trials for human use. In this write up we have tried to compile about marine-derived compounds anticancer biological activities of diverse flora and fauna and their underlying mechanisms and the generous raise in these compounds examined for malignant growth treatment in the course of the most recent quite a long while.
目前,海洋天然产物已被公认为生物活性物质和药物先导物的最重要来源。海洋动植物,如藻类、细菌、海绵、真菌、海藻、珊瑚、硅藻、海鞘等,是来自海洋的重要资源,占海洋总生物量的90%以上。它们在分类学上不同,具有巨大的生产力,是具有药理活性的新型化学特征,为发现新的抗癌分子提供了巨大机遇。水体是丰富的强效分子来源,这些分子可提高生存适应性,并作为抵御微生物和大小生物的化学屏障。这些分子表现出一系列生物学特性,如抗氧化、抗菌、抗肿瘤等。尽管海洋动植物富含令人兴奋的化学物质,但它们的抗癌特性在很大程度上尚未得到探索。最近,许多海洋抗癌化合物已被分离、表征、鉴定,并正在进行人体试验。在这篇文章中,我们试图汇编有关海洋来源化合物对不同动植物的抗癌生物活性及其潜在机制,以及在最近相当长一段时间内用于癌症治疗的这些化合物的大量增加情况。