Department of Orthopaedic Surgery, The University of Toledo, College of Medicine, Toledo, Ohio 43614, USA.
J Biomed Mater Res A. 2013 Aug;101(8):2436-47. doi: 10.1002/jbm.a.34521. Epub 2013 Feb 11.
This article reviews the potential injectable polymeric biomaterial scaffolds currently being investigated for application in bone tissue regeneration. Two types of injectable biomaterial scaffolds are focused in this review, including injectable microspheres and injectable gels. The injectable microspheres section covers several polymeric materials, including poly(L-lactide-co-glycolide)-PLGA, poly(propylene fumarate), and chitosan. The injectable gel section covers alginate gels, hyaluronan hydrogels, poly(ethylene-glycol)-PEG hydrogels, and PEG-PLGA copolymer hydrogels. This review focuses on the effect of cellular behavior in vitro and in vivo in terms of material properties of polymers, such as biodegradation, biocompatibility, porosity, microsphere size, and cross-linking nature. Injectable polymeric biomaterials offer a major advantage for orthopedic applications by allowing the ability to use noninvasive or minimally invasive treatment methods. Therefore, combining injectable polymeric biomaterial scaffolds with cells have a significant potential to treat orthopedic bone defects, including spine fusion, and craniofacial and periodontal defects.
本文综述了目前正在研究用于骨组织再生的潜在可注射聚合物生物材料支架。本综述重点介绍了两种可注射生物材料支架，包括可注射微球和可注射凝胶。可注射微球部分涵盖了几种聚合物材料，包括聚（L-丙交酯-共-乙交酯）-PLGA、聚（丙交酯-共-富马酸）和壳聚糖。可注射凝胶部分涵盖藻酸盐凝胶、透明质酸水凝胶、聚（乙二醇）-PEG 水凝胶和 PEG-PLGA 共聚物水凝胶。本综述重点关注了细胞行为在体外和体内的影响，从聚合物的材料特性方面来看，如生物降解性、生物相容性、孔隙率、微球大小和交联性质。可注射聚合物生物材料为矫形应用提供了一个主要优势，因为它允许使用非侵入性或微创治疗方法。因此，将可注射聚合物生物材料支架与细胞结合具有很大的潜力来治疗矫形骨缺损，包括脊柱融合以及颅面和牙周缺损。
