Haimov-Kochman Ronit, Brzezinski Amnon, Hochner-Celnikier Drorith
Division of Obstetrics and Gynaecology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
Eur J Contracept Reprod Health Care. 2008 Jun;13(2):133-7. doi: 10.1080/13625180801920131.
To evaluate adverse effects of herbal remedies consumed by menopausal women for control of the climacteric syndrome.
We examined the long term safety and herb-drug interactions of commonly used herbal therapy such as soy, black cohosh, dong quai, ginseng and vitamin E.
Even carefully designed studies on herbal treatments for vasomotor menopausal symptoms never addressed specifically safety issues. Sporadic reports show dangerous adverse effects of these herbal preparations as well as hazardous interactions between botanic compounds and conventional medications.
The unrestricted sale of plant products constitutes a new situation for physicians with little training in phytotherapy. The qualitative and quantitative diversity of the commercially available preparations, the absence of precise prescribing guidelines, and the risk of self-prescribed medication justify the introduction of 'phyto-vigilance'. Physicians should warn their patients about the lack of evidence regarding safety and possible interactions of herbal remedies with concurrent medications.
评估更年期女性为控制更年期综合征而服用的草药疗法的不良反应。
我们研究了常用草药疗法（如大豆、黑升麻、当归、人参和维生素E）的长期安全性及草药与药物的相互作用。
即使是精心设计的关于草药治疗更年期血管舒缩症状的研究，也从未专门涉及安全性问题。零星报告显示了这些草药制剂的危险不良反应以及植物化合物与传统药物之间的有害相互作用。
植物产品的无限制销售给几乎没有接受过植物疗法培训的医生带来了新情况。市售制剂在质量和数量上的多样性、缺乏精确的用药指南以及自我用药的风险证明引入“植物警戒”是合理的。医生应告知患者，关于草药安全性及其与同时服用药物可能产生的相互作用缺乏证据。
