Arizona Center for Integrative Medicine, University of Arizona, Tucson, AZ 85719, USA.
Maturitas. 2010 Aug;66(4):355-62. doi: 10.1016/j.maturitas.2010.03.008. Epub 2010 May 6.
Future research of herbal products for menopausal women should include long-term safety assessments because women may use these products for prolonged periods of time. Growing numbers of women take prescription medications and concurrently use herbal products for alleviation of menopausal symptoms. Because of possible herb-drug interactions, both drug and supplement manufacturers should provide basic pharmacokinetic data to reduce the risk of adverse interactions. In addition, herbal products produced to high quality standards are essential for ensuring consumer safety. Regulatory frameworks must be in place to ensure that herbal ingredients' identities have been verified, that they have been properly quantified per unit dose, that the product is within tolerance limits for contaminants, that the product's safety and effectiveness under the recommended conditions of use have been assessed before sale to the public, and that a system is in place to detect and deal with adverse reactions when they arise. This article explores these and related concerns.
未来针对更年期女性的草药产品研究应包括长期安全性评估，因为女性可能会长期使用这些产品。越来越多的女性服用处方药，并同时使用草药产品来缓解更年期症状。由于可能存在草药-药物相互作用，药物和补充剂制造商都应提供基本的药代动力学数据，以降低不良相互作用的风险。此外，必须采用高质量标准生产草药产品，以确保消费者安全。监管框架必须到位，以确保已验证草药成分的身份，已按单位剂量进行适当定量，产品在污染物的公差范围内，在向公众销售之前已评估产品在推荐使用条件下的安全性和有效性，并且建立了一个系统，以便在出现不良反应时进行检测和处理。本文探讨了这些问题和相关问题。
