Bestel Isabelle, Campins Nathalie, Marchenko Alexandr, Fichou Denis, Grinstaff Mark W, Barthélémy Philippe
Inserm, U869, F-33076 Bordeaux, France.
J Colloid Interface Sci. 2008 Jul 15;323(2):435-40. doi: 10.1016/j.jcis.2008.04.042. Epub 2008 Apr 24.
2D supramolecular structures on HOPG by self-assembly of physisorbed amphiphile nucleotides have been successfully imaged by high resolution STM. The organization of the systems depends on the nature of nucleic bases. In the case of the thymidine derivative a head-to-tail self-assembly is observed, whereas the amphiphile adenosine affords head-to-head nanostructures. The co-adsorption of complementary A+T amphiphile molecules induces the formation of a third head-to-head 2D supramolecular structure stabilized via base pairing. Molecular modelling calculations including the graphite surface provide models for all the 2D supramolecular systems observed.
通过物理吸附的两亲性核苷酸的自组装在高定向热解石墨（HOPG）上形成的二维超分子结构已通过高分辨率扫描隧道显微镜（STM）成功成像。这些体系的组织方式取决于核酸碱基的性质。在胸腺嘧啶衍生物的情况下，观察到了头对尾的自组装，而两亲性腺苷则形成了头对头的纳米结构。互补的A + T两亲性分子的共吸附诱导形成了通过碱基配对稳定的第三种头对头二维超分子结构。包括石墨表面在内的分子建模计算为观察到的所有二维超分子体系提供了模型。
