Gasteyger Christoph, Larsen Thomas Meinert, Vercruysse Frank, Astrup Arne
Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.
Am J Clin Nutr. 2008 May;87(5):1141-7. doi: 10.1093/ajcn/87.5.1141.
Weight loss was shown to be associated with improvements in liver enzymes and improvements of nonalcoholic fatty liver disease. However, some evidence also shows that liver enzymes may transiently increase immediately after a dietary-induced weight loss.
The aim was to assess the outcome of liver enzymes after a low-calorie diet (LCD) as well as during a follow-up period and to identify predictors for potential changes in these liver enzymes.
In this post hoc analysis of an existing database, liver enzymes were assessed before and immediately after a highly standardized soy-based meal replacement LCD providing 800 kcal/d, as well as 32 and 60 wk after the end of the LCD.
Data emanating from 147 obese subjects (104 women and 43 men) without known hepatic disease were included in this study. The LCD led to a median weight loss of 12.1 kg (range: 7.7-27.6 kg). In men, a significant decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was observed immediately after the LCD, whereas, in women, these enzymes increased significantly, although mildly; however, this increase was transient. Sex was the only identifiable predictor of these changes in liver enzymes.
This study showed that mild, transient increases in ALT and AST values can be observed immediately after an LCD in women, but not in men. These changes are probably of multifactorial origin and may be considered as benign as long as they remain transient.
体重减轻与肝酶改善及非酒精性脂肪性肝病的改善相关。然而，一些证据也表明，饮食诱导的体重减轻后肝酶可能会立即短暂升高。
评估低热量饮食（LCD）后以及随访期间肝酶的变化结果，并确定这些肝酶潜在变化的预测因素。
在对现有数据库的这项事后分析中，在提供800千卡/天的高度标准化大豆基代餐LCD之前、之后以及LCD结束后32周和60周评估肝酶。
本研究纳入了147名无已知肝病的肥胖受试者（104名女性和43名男性）的数据。LCD导致体重中位数减轻12.1千克（范围：7.7 - 27.6千克）。在男性中，LCD后立即观察到丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）显著下降，而在女性中，这些酶虽有轻度但显著升高；然而，这种升高是短暂的。性别是这些肝酶变化的唯一可识别预测因素。
本研究表明，女性在LCD后可立即观察到ALT和AST值轻度、短暂升高，而男性则不然。这些变化可能源于多因素，只要它们保持短暂，就可能被视为良性。
