Nanji A A, French S W, Freeman J B
Enzyme. 1986;36(4):266-9. doi: 10.1159/000469304.
We evaluated the change in serum alanine aminotransferase (ALT; EC 2.6.1.2) to serum aspartate aminotransferase (AST; EC 2.6.1.; ALT/AST) ratio with the degree of fatty liver in morbidly obese patients. A total of 31 patients were included in the study. Fatty liver was graded as 0 to 4+. The mean and SD of AST and ALT were not significantly different between groups of patients with various grades of fatty liver. There was, however, a significant correlation between the ALT/AST ratio and the degree of fatty infiltration of the liver. This, we believe, implies damage mainly to the plasma membrane allowing loss of cytoplasmic enzymes rather than loss of mitochondrial enzymes.
我们评估了病态肥胖患者血清丙氨酸氨基转移酶（ALT；EC 2.6.1.2）与血清天冬氨酸氨基转移酶（AST；EC 2.6.1.；ALT/AST）比值随脂肪肝程度的变化。共有31名患者纳入该研究。脂肪肝分级为0至4+。不同等级脂肪肝患者组之间AST和ALT的均值及标准差无显著差异。然而，ALT/AST比值与肝脏脂肪浸润程度之间存在显著相关性。我们认为，这意味着主要是质膜受损，导致细胞质酶流失，而非线粒体酶流失。
