Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Food Security Research Centre and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Clin Pract. 2022 Jan 31;2022:4982080. doi: 10.1155/2022/4982080. eCollection 2022.
The type and amount of dietary fats play an important role in fat accumulation in the liver. Sesame oil (SO) is a good source of monounsaturated acids (MUFAs) and polyunsaturated fatty acids (PUFAs).
This trial aimed at examining the effect of SO consumption on the levels of liver enzymes and the severity of fatty liver in women with nonalcoholic fatty liver disease (NAFLD) undergoing a weight loss diet.
This randomized, double-blind, controlled trial was carried out on 60 women with NAFLD. Subjects were randomly assigned to the SO group ( = 30) and sunflower oil (SFO) group ( = 30), each person consuming 30 grams of oil per day for 12 weeks. All the participants received a hypocaloric diet (-500 kcal/day) during the study. Fatty liver grade and liver enzymes were assessed at pre- and postintervention phases.
53 patients completed the study. Significant reductions in body weight, body mass index (BMI), waist circumference (WC), and fatty liver grade were observed in both groups ( < 0.05). Following SO, significant decreases in serum aspartate and alanine aminotransferases (AST and ALT) were observed. After adjusting for confounders, ALT, AST, and fatty liver grade of the SO group were significantly reduced compared to the SFO group ( < 0.05). However, the changes in serum alkaline phosphatase (ALP) were not significant ( > 0.05).
The desired effects of weight loss were reinforced by the consumption of SO through improving fatty liver severity and serum ALT and AST levels in NAFLD patients. Moreover, low-calorie diets may lead to favorable outcomes for NAFLD patients through mitigation of obesity and fatty liver grade.
膳食中脂肪的种类和数量对肝脏脂肪堆积起着重要作用。芝麻油（SO）是单不饱和脂肪酸（MUFA）和多不饱和脂肪酸（PUFA）的良好来源。
本试验旨在研究食用 SO 对接受减肥饮食的非酒精性脂肪肝（NAFLD）女性的肝酶水平和脂肪肝严重程度的影响。
这是一项随机、双盲、对照试验，共纳入 60 名 NAFLD 女性患者。受试者被随机分为 SO 组（n=30）和葵花籽油（SFO）组（n=30），每天各摄入 30 克油，共 12 周。所有参与者在研究期间均接受低热量饮食（每天减少 500 千卡）。在干预前后评估脂肪肝分级和肝酶。
53 例患者完成了研究。两组体重、体重指数（BMI）、腰围（WC）和脂肪肝分级均显著降低（<0.05）。SO 组血清天门冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）显著降低。调整混杂因素后，与 SFO 组相比，SO 组 ALT、AST 和脂肪肝分级显著降低（<0.05）。然而，血清碱性磷酸酶（ALP）的变化不显著（>0.05）。
通过改善 NAFLD 患者的脂肪肝严重程度和血清 ALT、AST 水平，食用 SO 可增强减肥的效果。此外，低热量饮食可能通过减轻肥胖和脂肪肝分级，为 NAFLD 患者带来有利的结果。
