Grivea Ioanna N, Panagiotou Maria, Tsantouli Alexandra G, Syrogiannopoulos George A
Department of Pediatrics, University of Thessaly, School of Medicine, General University Hospital, Larissa, Greece.
Pediatr Infect Dis J. 2008 Jun;27(6):519-25. doi: 10.1097/INF.0b013e318168d28a.
In Greece, the heptavalent pneumococcal conjugate vaccine (PCV7) became available in October 2004 and it was incorporated into the national immunization schedule in January 2006.
In February 2005, a yearly surveillance of the nasopharyngeal colonization with Streptococcus pneumoniae in children attending day-care centers in Central Greece began.
Between February 2005 and May 2007, nasopharyngeal cultures were obtained from 1829 children aged 13-76 months (median age, 47 months). The proportion of attendees vaccinated with > or =1 doses of PCV7 increased from 13% (2005) to 33% (2006) and to 70% (2007); 98% had been immunized on toddler catch-up schedules. Among vaccinated carriers, the proportion of PCV7 serotypes decreased from 33% (2005) to 29% (2006) and to 8.6% (2007) (chi for trend, P < 0.001), the proportion of PCV7-related serotypes increased from 13% (2005) to 26% (2006) and to 28% (2007) (P = 0.16), whereas the proportion of non-PCV7 serotypes was 48% in 2005, 31% in 2006, and 55% in 2007 (P = 0.17). The proportion of PCV7 serotypes declined also among unvaccinated carriers. The carriage of serotype 19A did not increase. Among vaccinated carriers, the rate of highly penicillin-resistant isolates decreased from year 1 to year 3, respectively, 11%, 7.7%, and 0.6% (P = 0.001), whereas the proportion of penicillin-intermediate pneumococci was 13% in 2005, 23% in 2006, and 26% in 2007 (P = 0.22).
In Central Greece, widespread PCV vaccination was followed by a significant reduction of carriage of highly penicillin-resistant pneumococci. The frequency of penicillin-intermediate isolates did not change significantly among vaccinated carriers.
在希腊，七价肺炎球菌结合疫苗（PCV7）于2004年10月上市，并于2006年1月纳入国家免疫规划。
2005年2月，开始对希腊中部日托中心儿童的肺炎链球菌鼻咽定植情况进行年度监测。
2005年2月至2007年5月，从1829名年龄在13 - 76个月（中位年龄47个月）的儿童中获取了鼻咽培养物。接种≥1剂PCV7的儿童比例从2005年的13%增至2006年的33%，并于2007年达到70%；98%是按照幼儿补种计划进行免疫接种的。在接种疫苗的带菌者中，PCV7血清型的比例从2005年的33%降至2006年的29%，并于2007年降至8.6%（趋势χ检验，P<0.001），与PCV7相关血清型的比例从2005年的13%增至2006年的26%，并于2007年增至28%（P = 0.16），而非PCV7血清型的比例在2005年为48%，2006年为31%，2007年为55%（P = 0.17）。未接种疫苗的带菌者中PCV7血清型的比例也有所下降。19A血清型的定植未增加。在接种疫苗的带菌者中，高度耐青霉素菌株的比例从第1年到第3年分别下降，为11%、7.7%和0.6%（P = 0.001），而青霉素中介肺炎球菌的比例在2005年为13%，2006年为23%，2007年为26%（P = 0.22）。
在希腊中部，广泛接种PCV疫苗后，高度耐青霉素肺炎球菌的定植显著减少。在接种疫苗的带菌者中，青霉素中介菌株的频率没有显著变化。
