Lau Benjamin P-Y, Becalski Adam
Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada, K1A 0K9.
Rapid Commun Mass Spectrom. 2008 Jun;22(12):1787-91. doi: 10.1002/rcm.3547.
A rapid analytical method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) using electrospray ionization in negative ion detection mode was developed for the analysis of underivatized iodoacetic acid in water. The method was applied to model reaction mixtures in the study of the formation of iodoacetic acid after chlorinated tap water was boiled in the presence of potassium iodide or iodized table salt. Samples can be directly analyzed by the LC/MS/MS system without extraction or chemical derivatization. Limit of detection was determined to be 0.3 microg/L (or 0.3 ng/mL) and limit of quantitation was about 1 microg/L (1 ng/mL).
建立了一种基于液相色谱/串联质谱（LC/MS/MS）的快速分析方法，该方法采用负离子检测模式下的电喷雾电离，用于分析水中未衍生化的碘乙酸。该方法应用于在碘化钾或加碘食盐存在下煮沸氯化自来水后碘乙酸形成研究中的模拟反应混合物。样品无需萃取或化学衍生化，可直接通过LC/MS/MS系统进行分析。检测限确定为0.3微克/升（或0.3纳克/毫升），定量限约为1微克/升（1纳克/毫升）。
