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在酸化唾液中乙醇向亚硝酸乙酯的转化：其在胃中发生的可能性。

Transformation of ethyl alcohol to ethyl nitrite in acidified saliva: possibility of its occurrence in the stomach.

作者信息

Takahama Umeo, Tanaka Mariko, Hirota Sachiko

机构信息

Department of Bioscience, Kyushu Dental College, Manazuru 2-6-1, Kitakyushu 803-8580, Japan.

出版信息

Arch Biochem Biophys. 2008 Jul 15;475(2):135-9. doi: 10.1016/j.abb.2008.04.021. Epub 2008 Apr 26.

DOI:10.1016/j.abb.2008.04.021
PMID:18471427
Abstract

After taking alcoholic beverages, the ethanol is mixed with saliva and then gastric juice. As pH of gastric juice is around 2, the ethanol might be transformed to ethyl nitrite in the stomach by reacting with salivary nitrite. In this study, reactions between ethanol and nitrite in acidified saliva were investigated. The result indicates that nitrite in acidified saliva reacted with ethanol producing ethyl nitrite. It is discussed that ethyl nitrite might be formed in the stomach after drinking alcoholic beverages and that the ethyl nitrite might function as a donor of NO in intestinal and gastric tissues.

摘要

摄入酒精饮料后，乙醇会与唾液混合，然后再与胃液混合。由于胃液的pH值约为2，乙醇可能会在胃中与唾液中的亚硝酸盐反应转化为亚硝酸乙酯。在本研究中，对酸化唾液中乙醇与亚硝酸盐之间的反应进行了研究。结果表明，酸化唾液中的亚硝酸盐与乙醇反应生成了亚硝酸乙酯。讨论了饮酒后胃中可能形成亚硝酸乙酯，并且亚硝酸乙酯可能在肠道和胃组织中作为一氧化氮的供体发挥作用。

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