2型糖尿病患者龈沟液中前列腺素E2、白细胞介素-1β、组织型纤溶酶原激活剂、纤溶酶原激活物抑制剂-2水平及其与牙周病的关系。
Gingival crevicular fluid PGE2, IL-1beta, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease.
作者信息
Kardeşler Levent, Buduneli Nurcan, Biyikoğlu Başak, Cetinkalp Sevki, Kütükçüler Necil
机构信息
Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey.
出版信息
Clin Biochem. 2008 Jul;41(10-11):863-8. doi: 10.1016/j.clinbiochem.2008.04.013. Epub 2008 Apr 26.
OBJECTIVES
To evaluate if type 2 diabetes mellitus increase gingival crevicular fluid (GCF) levels of prostaglandin E(2) (PGE(2)), interleukin-1beta (IL-1beta), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor-2 (PAI-2).
DESIGN AND METHODS
Seventeen type 2 diabetic patients with periodontal disease (DM), 17 otherwise healthy periodontally diseased patients (PD) and 17 systemically and periodontally healthy control subjects (H) were enrolled. Clinical periodontal measurements were recorded at six sites/tooth. GCF samples were analyzed by ELISA. Data were tested by statistical tests.
RESULTS
DM group revealed lower IL-1beta levels than PD group (p<0.01). PGE(2), t-PA and PAI-2 levels were similar in DM and PD groups (p>0.05). PGE(2), t-PA levels were higher in DM and PD groups than H group (p<0.05). PAI-2 level was higher in DM group than H group (p<0.05). GCF total amount of PGE(2) in DM group exhibited significant correlations with all clinical periodontal measurements (p<0.05).
CONCLUSION
Type 2 diabetes in this study seems not to increase GCF levels of the evaluated inflammatory mediators.
目的
评估2型糖尿病是否会增加龈沟液（GCF）中前列腺素E2（PGE2）、白细胞介素-1β（IL-1β）、组织型纤溶酶原激活剂（t-PA）和纤溶酶原激活剂抑制剂-2（PAI-2）的水平。
设计与方法
纳入17名患有牙周病的2型糖尿病患者（DM）、17名其他方面健康的牙周病患者（PD）和17名全身及牙周健康的对照受试者（H）。在每个牙齿的六个位点记录临床牙周测量数据。通过酶联免疫吸附测定法（ELISA）分析龈沟液样本。数据采用统计学检验。
结果
DM组的IL-1β水平低于PD组（p<0.01）。DM组和PD组的PGE2、t-PA和PAI-2水平相似（p>0.05）。DM组和PD组的PGE2、t-PA水平高于H组（p<0.05）。DM组的PAI-2水平高于H组（p<0.05）。DM组中PGE2的龈沟液总量与所有临床牙周测量值均呈显著相关性（p<0.05）。
结论
本研究中的2型糖尿病似乎不会增加所评估的炎症介质的龈沟液水平。
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