Naghipour Mohammadreza, Nakagomi Toyoko, Nakagomi Osamu
Division of Molecular Epidemiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Vaccine. 2008 Jun 19;26(26):3236-41. doi: 10.1016/j.vaccine.2008.04.004. Epub 2008 Apr 24.
More than 65% of the global rotavirus deaths were estimated to occur in 11 countries in Asia and Africa, claiming 345,000 children less than 5 years of age in 2004. While efficacious rotavirus vaccines are at hand, inequity in health delivery system within and between these countries was found to be the major hurdle against achieving the goal of rotavirus vaccine. When the coverage of currently used vaccines was applied to a rotavirus vaccine, a maximum of 202,550 deaths would be averted. Even if the coverage reached 80%, there would remain 96,841 children dying because of rotavirus diarrhea in these 11 countries. Studies are therefore encouraged to develop comprehensive strategies to resolve inequity in health delivery system enabling the increase in the immunization coverage.
据估计，全球超过65%的轮状病毒死亡病例发生在亚洲和非洲的11个国家，2004年有34.5万名5岁以下儿童因此死亡。虽然有效的轮状病毒疫苗已经问世，但这些国家内部以及国家之间卫生服务体系的不平等被认为是实现轮状病毒疫苗目标的主要障碍。若将目前使用疫苗的覆盖率应用于轮状病毒疫苗，最多可避免202,550例死亡。即便覆盖率达到80%，这11个国家仍会有96,841名儿童因轮状病毒腹泻死亡。因此，鼓励开展研究以制定全面战略，解决卫生服务体系中的不平等问题，从而提高免疫覆盖率。
