Department of Cell Biology and Immunology Faculty of Medicine Vrije Universiteit Van der Boechorststraat 7 Amsterdam 1081 BT The Netherlands.
Mediators Inflamm. 1997;6(2):85-93. doi: 10.1080/09629359791776.
Emigration of leukocytes from the circulation into tissue by transendothelial migration, is mediated subsequently by adhesion molecules such as selectins, chemokines and integrins. This multistep paradigm, with multiple molecular choices at each step, provides a diversity in signals. The influx of neutrophils, monocytes and lymphocytes into inflamed tissue is important in the pathogenesis of chronic inflammatory bowel disease. The importance of each of these groups of adhesion molecules in chronic inflammatory bowel disease, either in human disease or in animal models, will be discussed below. Furthermore, the possibilities of blocking these different steps in the process of leukocyte extravasation in an attempt to prevent further tissue damage, will be taken into account.
白细胞从血液循环中穿过血管内皮迁移到组织中，随后通过黏附分子（如选择素、趋化因子和整合素）介导。这种多步骤范例在每个步骤都有多个分子选择，提供了多样性的信号。中性粒细胞、单核细胞和淋巴细胞流入炎症组织在慢性炎症性肠病的发病机制中很重要。下面将讨论这些黏附分子在慢性炎症性肠病中的重要性，无论是在人类疾病还是动物模型中。此外，还将考虑阻断白细胞渗出过程中的这些不同步骤的可能性，以防止进一步的组织损伤。
