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某些2-取代-1H-苯并咪唑的d金属配合物的合成、表征及抗菌活性

Synthesis, Characterization and Antimicrobial Activity of d Metal Complexes of some 2-Substituted-1H-Benzimidazoles.

作者信息

Ulküseven B, Tavman A, Otük G

机构信息

Istanbul University Faculty of Engineering Science Department of Chemistry Avcılar Istanbul Turkey.

出版信息

Met Based Drugs. 1999;6(3):163-7. doi: 10.1155/MBD.1999.163.

DOI:10.1155/MBD.1999.163
PMID:18472907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366824/
Abstract

The metal complexes of nine 2-substituted-1H-benzimidazoles (I-IX) with Ni(II), Pd(II), Cu(II), Ag(I), Zn(II) salts were synthesized. The compounds were characterized by melting point, analytical data, IR spectroscopy and magnetic susceptibility. The antimicrobial activity of the compounds was determined by the disk diffusion method in Mueller-Hinton Agar on Staphylococcus aureusATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis, Candida albicans ATCC 10231. Cu(II)and Ag(I)complexes of II, III and IV showed considerable activity against S. aureus, S. epidermidis, Ps. aeruginosa, S. typhi, Sh. flexneri and C. albicans microorganisms, the ligands themselves having no effect.

摘要

合成了9种2-取代-1H-苯并咪唑（I-IX）与镍（II）、钯（II）、铜（II）、银（I）、锌（II）盐的金属配合物。通过熔点、分析数据、红外光谱和磁化率对这些化合物进行了表征。采用纸片扩散法在穆勒-欣顿琼脂培养基上对金黄色葡萄球菌ATCC 6538、表皮葡萄球菌ATCC 12228、大肠杆菌ATCC 8739、肺炎克雷伯菌ATCC 4352、铜绿假单胞菌ATCC 1539、伤寒沙门氏菌、福氏志贺氏菌、奇异变形杆菌、白色念珠菌ATCC 10231测定了这些化合物的抗菌活性。II、III和IV的铜（II）和银（I）配合物对金黄色葡萄球菌、表皮葡萄球菌、铜绿假单胞菌、伤寒沙门氏菌、福氏志贺氏菌和白色念珠菌等微生物表现出相当强的活性，而配体本身没有作用。

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