Ulküseven B, Tavman A, Otük G, Birteksöz S
Department of Chemistry, Faculty of Engineering, Istanbul University, 34850 Avcilar, Istanbul, Turkey.
Folia Microbiol (Praha). 2002;47(5):481-7. doi: 10.1007/BF02818785.
Antimicrobial activity of 2-(2-hydroxyphenyl)-5-R5-1H-benzimidazoles, 2-(2-hydroxy-5-R5'-phenyl)-1H-benzimidazoles and their FeIII, CuII, AgI, ZnII and HgII nitrate complexes was tested toward Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, and Proteus mirabilis. Antifungal activity was tested against Candida albicans. Benzimidazole benzene ring substituents increase the antimicrobial activity, phenol ring substituents decrease it. The ligands show an antibacterial effect against only S. aureus whereas AgI and HgII complexes of the ligands have a higher activity with respect to the other complexes to all the bacteria. On the other hand, FeIII complexes show a considerable activity against S. aureus and S. epidermidis.
测试了2-(2-羟基苯基)-5-R5-1H-苯并咪唑、2-(2-羟基-5-R5'-苯基)-1H-苯并咪唑及其硝酸铁(III)、硝酸铜(II)、硝酸银(I)、硝酸锌(II)和硝酸汞(II)配合物对金黄色葡萄球菌、表皮葡萄球菌、大肠杆菌、肺炎克雷伯菌、铜绿假单胞菌、伤寒沙门氏菌、福氏志贺菌和奇异变形杆菌的抗菌活性。测试了其对白色念珠菌的抗真菌活性。苯并咪唑苯环取代基增加抗菌活性，酚环取代基降低抗菌活性。配体仅对金黄色葡萄球菌显示抗菌作用，而配体的硝酸银(I)和硝酸汞(II)配合物对所有细菌的活性高于其他配合物。另一方面，硝酸铁(III)配合物对金黄色葡萄球菌和表皮葡萄球菌显示出相当高的活性。
