Tavman A, Ulküseven B, Birteksöz S, Otük G
Department of Chemistry, Faculty of Engineering, Istanbul University, 34850 Avcilar, Istanbul, Turkey.
Folia Microbiol (Praha). 2003;48(4):479-83. doi: 10.1007/BF02931328.
2-(2-Pyridinyl)- (LI), 2-(6-methyl-2-pyridinyl)- (LII), 2-(6-methyl-2-pyridinyl)-5-methyl-(LIII), 2-(3-pyridinyl)- (LIV), 2-(3-pyridinyl)-5-methyl-1H-benzimidazoles (LV) and their complexes with Fe(NO3)3, Cu(NO3)2, Zn(NO3)2, and AgNO3 were synthesized and antibacterial activity of the compounds was tested toward Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis and antifungal activity against Candida albicans. The methyl groups of LIII increase the antimicrobial activity. The AgI complexes have considerable activity toward the microorganisms. Some ZnII complexes show an antimicrobial effect against S. aureus and S. flexneri, although the ligands themselves have no effect. CuII complexes have a considerable antibacterial effect to S. aureus and S. epidermidis.
合成了2-(2-吡啶基)-(LI)、2-(6-甲基-2-吡啶基)-(LII)、2-(6-甲基-2-吡啶基)-5-甲基-(LIII)、2-(3-吡啶基)-(LIV)、2-(3-吡啶基)-5-甲基-1H-苯并咪唑(LV)及其与Fe(NO₃)₃、Cu(NO₃)₂、Zn(NO₃)₂和AgNO₃的配合物，并测试了这些化合物对金黄色葡萄球菌、表皮葡萄球菌、大肠杆菌、肺炎克雷伯菌、铜绿假单胞菌、伤寒沙门氏菌、宋内志贺菌、奇异变形杆菌的抗菌活性以及对白色念珠菌的抗真菌活性。LIII的甲基增强了抗菌活性。AgI配合物对微生物具有相当大的活性。一些ZnII配合物对金黄色葡萄球菌和宋内志贺菌显示出抗菌作用，尽管配体本身没有作用。CuII配合物对金黄色葡萄球菌和表皮葡萄球菌有相当大的抗菌作用。
