1-羟基蒽醌对醋酸甲基氧化偶氮甲醇诱导的大鼠致癌作用的协同效应。

The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats.

作者信息

Mori Y, Yoshimi N, Iwata H, Tanaka T, Mori H

机构信息

First Department of Pathology, Gifu University School of Medicine, Japan.

出版信息

Carcinogenesis. 1991 Feb;12(2):335-8. doi: 10.1093/carcin/12.2.335.

DOI:10.1093/carcin/12.2.335

PMID:1847322

Abstract

The synergistic potential of 1-hydroxyanthraquinone (1-HA) on methylazoxymethanol (MAM) acetate-induced carcinogenesis was investigated in rats. A total of 154 inbred ACI/N rats (73 males and 81 females), six weeks old at the start of the experiment, were divided into four groups: group 1 was given i.p. injections of MAM acetate (25 mg/kg body wt), once per week for 2 weeks and then fed the diet containing 1% 1-HA for 42 weeks; group 2 received MAM acetate and was kept on the basal diet alone; group 3 was given 1-HA containing diet alone as for group 1; group 4 was treated as a control. At the termination of the experiment, the carcinogenic effect of MAM acetate and 1-HA in the large bowel or liver exceeded the sum of effects when given alone, indicating that the two chemicals act synergistically in the carcinogenesis of these organs.

摘要

在大鼠中研究了1-羟基蒽醌（1-HA）对乙酸甲基偶氮甲醇（MAM）诱导致癌作用的协同潜力。实验开始时共有154只近交系ACI/N大鼠（73只雄性和81只雌性），六周龄，分为四组：第1组腹腔注射乙酸MAM（25mg/kg体重），每周一次，共2周，然后喂食含1% 1-HA的饲料42周；第2组接受乙酸MAM并仅喂食基础饲料；第3组与第1组一样仅喂食含1-HA的饲料；第4组作为对照。实验结束时，乙酸MAM和1-HA在大肠或肝脏中的致癌作用超过单独给药时的作用总和，表明这两种化学物质在这些器官的致癌过程中起协同作用。