Kato K, Kawai T, Fujii M, Bunai Y, Shima H, Takahashi M
J Toxicol Sci. 1985 Nov;10(4):289-93. doi: 10.2131/jts.10.289.
This study concerns the modifying effect of carbon tetrachloride (CCl4) on methylazoxymethanol acetate (MAM)-induced intestinal carcinogenesis in ACI rats of both sexes. Forty five animals were given CCl4 (0.5 ml/kg body weight) through a stomach tube, followed by an i.p. injection with MAM (25 mg/kg body weight) 24 hours after CCl4 treatment. The paired administrations were done once a week for 4 weeks and animals were observed until sacrifice 30 weeks later. Pretreatment with CCl4 caused not only early death from chemical toxicity of MAM but also an increase in small-bowel tumors.
本研究关注四氯化碳（CCl4）对乙酸甲基氧化偶氮甲醇（MAM）诱导的雄性和雌性ACI大鼠肠道癌变的修饰作用。45只动物通过胃管给予CCl4（0.5 ml/kg体重），在CCl4处理24小时后腹腔注射MAM（25 mg/kg体重）。每周进行一次配对给药，共4周，观察动物直至30周后处死。CCl4预处理不仅导致MAM化学毒性引起的早期死亡，还导致小肠肿瘤增加。
