轻度缺乏促脂物质的饮食对乙酸甲基偶氮甲醇致癌作用的影响。

Effect of a marginally lipotrope-deficient diet on methylazoxymethanol acetate carcinogenesis.

作者信息

Kato K, Mori H, Takahashi M, Hirono I

出版信息

Nutr Cancer. 1982;3(4):234-9. doi: 10.1080/01635588109513727.

Abstract

The effect of a lipotrope-deficient diet on methylazoxymethanol acetate (MAM acetate) intestinal carcinogenesis was studied in 2 groups of ACI rats. For 10 weeks, weanling rats were fed a semisynthetic diet that was either high in fat and marginally deficient in the lipotropes (Group 1), or adequate for rats in all known respects (Group 2). Four weeks after the start of the experimental diets, the animals were given a weekly SC injection of MAM acetate, 25 mg/kg body weight, for a total of 5 times. Following the termination of the experimental diets, the animals were fed a basal diet until the end of the experiment (480 days). The tumor incidence in the jejunum-ileum and the number of tumors in the colon were significantly higher in Group 1 than in Group 2. These results suggest that a marginally lipotrope-deficient diet enhances MAM acetate carcinogenesis, probably in its early stage.

摘要

在两组ACI大鼠中研究了缺乏促脂物质的饮食对乙酸甲基偶氮甲醇（MAM乙酸酯）肠道致癌作用的影响。将断奶大鼠喂以半合成饮食10周，该饮食要么脂肪含量高且促脂物质略微缺乏（第1组），要么在所有已知方面对大鼠而言都是充足的（第2组）。在实验饮食开始4周后，给动物每周皮下注射一次MAM乙酸酯，剂量为25 mg/kg体重，共注射5次。在实验饮食结束后，给动物喂以基础饮食直至实验结束（480天）。第1组空肠-回肠的肿瘤发生率和结肠中的肿瘤数量显著高于第2组。这些结果表明，略微缺乏促脂物质的饮食可能在早期增强了MAM乙酸酯的致癌作用。