Richardson Stephen M, Hoyland Judith A
Tissue Injury and Repair Group, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Curr Pain Headache Rep. 2008 Apr;12(2):83-8. doi: 10.1007/s11916-008-0016-3.
Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there is a growing interest in the potential of cell-based tissue engineering strategies for regeneration of the damaged IVD. To achieve this, investigators are now focusing on the use of mesenchymal stem cells (MSCs), which offer several advantages over more mature cell types. A number of problems must be overcome for MSC-based IVD regeneration to be successful, including determining a method for the differentiation of stem cells into nucleus pulposus-like cells. Although this is still a relatively new field, it offers huge potential for the clinical treatment of IVD degeneration and LBP in the future.
腰痛（LBP）是最常见的肌肉骨骼疾病之一，大多数病例都与椎间盘（IVD）退变有关。尽管有许多治疗选择，但它们侧重于症状的消除而非退变组织的修复。然而，基于细胞的组织工程策略在受损IVD再生方面的潜力正受到越来越多的关注。为了实现这一目标，研究人员目前正专注于间充质干细胞（MSC）的使用，与更成熟的细胞类型相比，MSC具有若干优势。基于MSC的IVD再生要取得成功，必须克服许多问题，包括确定将干细胞分化为髓核样细胞的方法。尽管这仍然是一个相对较新的领域，但它在未来IVD退变和LBP的临床治疗方面具有巨大潜力。
