间充质干细胞：细胞治疗的新趋势。
Mesenchymal stem cells: a new trend for cell therapy.
机构信息
Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
出版信息
Acta Pharmacol Sin. 2013 Jun;34(6):747-54. doi: 10.1038/aps.2013.50.
Abstract
Mesenchymal stem cells (MSCs), the major stem cells for cell therapy, have been used in the clinic for approximately 10 years. From animal models to clinical trials, MSCs have afforded promise in the treatment of numerous diseases, mainly tissue injury and immune disorders. In this review, we summarize the recent opinions on methods, timing and cell sources for MSC administration in clinical applications, and provide an overview of mechanisms that are significant in MSC-mediated therapies. Although MSCs for cell therapy have been shown to be safe and effective, there are still challenges that need to be tackled before their wide application in the clinic.
摘要
间充质干细胞（MSCs）是细胞治疗的主要干细胞，已经在临床上应用了大约 10 年。从动物模型到临床试验，MSCs 在治疗许多疾病方面都有希望，主要是组织损伤和免疫紊乱。在这篇综述中，我们总结了最近关于 MSC 临床应用中给药方法、时间和细胞来源的意见，并概述了在 MSC 介导的治疗中具有重要意义的机制。尽管细胞治疗用 MSCs 已被证明是安全有效的，但在其广泛应用于临床之前，仍需要解决一些挑战。
相似文献
1
Mesenchymal stem cells: a new trend for cell therapy.间充质干细胞：细胞治疗的新趋势。
Acta Pharmacol Sin. 2013 Jun;34(6):747-54. doi: 10.1038/aps.2013.50.
2
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.胚胎干细胞衍生的细胞外囊泡增强间充质干细胞的治疗效果。
Theranostics. 2019 Sep 21;9(23):6976-6990. doi: 10.7150/thno.35305. eCollection 2019.
3
Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.用于治疗免疫和炎症介导疾病的人间充质干细胞：当前临床试验综述
J Biomed Sci. 2016 Nov 4;23(1):76. doi: 10.1186/s12929-016-0289-5.
4
MSC-Based Cell Therapy in Neurological Diseases: A Concise Review of the Literature in Pre-Clinical and Clinical Research.基于间充质干细胞的神经疾病细胞治疗：临床前和临床研究文献的简明综述。
Biomolecules. 2024 Apr 30;14(5):538. doi: 10.3390/biom14050538.
5
Advancing Mesenchymal Stem Cell Therapy with CRISPR/Cas9 for Clinical Trial Studies.利用 CRISPR/Cas9 推进间充质干细胞疗法的临床试验研究。
Adv Exp Med Biol. 2020;1247:89-100. doi: 10.1007/5584_2019_459.
6
Are mesenchymal stromal cells immune cells?间充质基质细胞是免疫细胞吗？
Arthritis Res Ther. 2015 Mar 31;17(1):88. doi: 10.1186/s13075-015-0596-3.
7
Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles as novel cell-free therapy for treatment of autoimmune disorders.间充质干细胞衍生的细胞外囊泡作为治疗自身免疫性疾病的新型无细胞疗法的治疗潜力。
Exp Mol Pathol. 2021 Feb;118:104566. doi: 10.1016/j.yexmp.2020.104566. Epub 2020 Nov 6.
8
Immunosuppressive properties of mesenchymal stem cells.间充质干细胞的免疫抑制特性。
Stem Cell Rev Rep. 2012 Jun;8(2):375-92. doi: 10.1007/s12015-011-9312-0.
9
Does the route matter? A preclinical review of mesenchymal stromal cell delivery to the kidney.途径重要吗？间充质基质细胞向肾脏输送的临床前综述。
APMIS. 2023 Dec;131(12):687-697. doi: 10.1111/apm.13352. Epub 2023 Sep 25.
10
Therapeutic Potential of Mesenchymal Stem Cells in Immune-Mediated Diseases.间充质干细胞在免疫介导性疾病中的治疗潜力。
Adv Exp Med Biol. 2019;1201:93-108. doi: 10.1007/978-3-030-31206-0_5.
引用本文的文献
1
Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate AKI after cardiac surgery by facilitating miR-21-5p targeting TEAD1.源自人脐带间充质干细胞的外泌体通过促进miR-21-5p靶向TEAD1改善心脏手术后的急性肾损伤。
Ren Fail. 2025 Dec;47(1):2537797. doi: 10.1080/0886022X.2025.2537797. Epub 2025 Aug 7.
2
Mesenchymal stem cell-derived exosomes-a promising therapeutic approach to improve neurocognitive disorders in chronic obstructive pulmonary disease.间充质干细胞衍生的外泌体——一种改善慢性阻塞性肺疾病神经认知障碍的有前景的治疗方法。
Stem Cell Res Ther. 2025 Jun 20;16(1):314. doi: 10.1186/s13287-025-04457-5.
3
3D bioprinted scaffolds for osteochondral regeneration: advancements and applications.用于骨软骨再生的3D生物打印支架：进展与应用
Mater Today Bio. 2025 May 8;32:101834. doi: 10.1016/j.mtbio.2025.101834. eCollection 2025 Jun.
4
Differentiation of Adipose-Derived Stromal/Stem Cells into Osteocytes.脂肪来源的基质/干细胞向骨细胞的分化。
Methods Mol Biol. 2025;2938:145-154. doi: 10.1007/978-1-0716-4607-6_17.
5
Systemic aging delay and anti-aging therapy using allogeneic stem cells.使用同种异体干细胞的全身衰老延迟和抗衰老治疗。
Korean J Fam Med. 2025 May;46(3):127-136. doi: 10.4082/kjfm.25.0080. Epub 2025 May 20.
6
Stem cell therapy use in patients with dementia: a systematic review.干细胞疗法在痴呆患者中的应用：一项系统综述。
Int J Emerg Med. 2025 May 12;18(1):95. doi: 10.1186/s12245-025-00876-6.
7
Footprint-free induced pluripotent stem cells can be successfully differentiated into mesenchymal stromal cells in the feline model.在猫科动物模型中，无足迹诱导多能干细胞可成功分化为间充质基质细胞。
Stem Cell Res Ther. 2025 Apr 20;16(1):195. doi: 10.1186/s13287-025-04325-2.
8
Functional aligned mesenchymal stem cell sheets fabricated using micropatterned thermo-responsive cell culture surfaces.使用微图案化热响应性细胞培养表面制备的功能性对齐间充质干细胞片。
Mater Today Bio. 2025 Mar 10;32:101657. doi: 10.1016/j.mtbio.2025.101657. eCollection 2025 Jun.
9
Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword.多发性骨髓瘤患者骨髓微环境中的间充质基质细胞：一把双刃剑。
Cancer Cell Int. 2025 Mar 26;25(1):117. doi: 10.1186/s12935-025-03741-x.
10
Physiologically-Modeled Dynamic Stimulation and Growth Factors Induce Differentiation of Mesenchymal Stem Cells to a Vascular Endothelial Cell Phenotype.生理模型动态刺激和生长因子诱导间充质干细胞分化为血管内皮细胞表型。
Microcirculation. 2025 Apr;32(3):e70007. doi: 10.1111/micc.70007.
本文引用的文献
1
The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth.间充质干细胞的免疫抑制作用在组织修复和肿瘤生长中的作用。
Cell Biosci. 2012 Mar 5;2(1):8. doi: 10.1186/2045-3701-2-8.
2
Epithelial-Mesenchymal Transition in tumor microenvironment.肿瘤微环境中的上皮-间充质转化。
Cell Biosci. 2011 Aug 31;1:29. doi: 10.1186/2045-3701-1-29.
3
Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-α stimulated gene/protein 6.远程作用：系统给予的成体干细胞（MSCs）通过分泌 TNF-α 刺激基因/蛋白 6 减少对角膜的炎症损伤，而没有植入和主要作用。
Stem Cells. 2011 Oct;29(10):1572-9. doi: 10.1002/stem.708.
4
Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease.白血病抑制因子抑制辅助性 T 细胞 17 分化，并赋予神经祖细胞治疗自身免疫性疾病的治疗效果。
Immunity. 2011 Aug 26;35(2):273-84. doi: 10.1016/j.immuni.2011.06.011. Epub 2011 Aug 11.
5
Remestemcel-L: human mesenchymal stem cells as an emerging therapy for Crohn's disease.Remestemcel-L：人骨髓间充质干细胞作为一种新兴的克罗恩病治疗方法。
Expert Opin Biol Ther. 2011 Sep;11(9):1249-56. doi: 10.1517/14712598.2011.602967. Epub 2011 Jul 25.
6
Immunosuppressive cells and tumour microenvironment: focus on mesenchymal stem cells and myeloid derived suppressor cells.免疫抑制细胞与肿瘤微环境：聚焦间充质干细胞与髓系来源抑制细胞。
Histol Histopathol. 2011 Jul;26(7):941-51. doi: 10.14670/HH-26.941.
7
Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes.乙型肝炎所致肝衰竭患者自体骨髓间充质干细胞移植：短期和长期疗效。
Hepatology. 2011 Sep 2;54(3):820-8. doi: 10.1002/hep.24434. Epub 2011 Jul 14.
8
Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer.炎症因子对间充质干细胞的影响及其在促进结肠癌肿瘤血管生成中的作用。
J Biol Chem. 2011 Jul 15;286(28):25007-15. doi: 10.1074/jbc.M110.213108. Epub 2011 May 18.
9
Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice.骨髓间充质基质细胞抑制小鼠 Th2 介导的过敏性气道炎症。
Stem Cells. 2011 Jul;29(7):1137-48. doi: 10.1002/stem.656.
10
Effective treatment of severe steroid-resistant acute graft-versus-host disease with umbilical cord-derived mesenchymal stem cells.脐带间充质干细胞治疗重症激素耐药急性移植物抗宿主病的疗效观察。
Transplantation. 2011 Jun 27;91(12):1412-6. doi: 10.1097/TP.0b013e31821aba18.
Zotero 插件