Schubert Mitchell L, Peura David A
Department of Medicine, Division of Gastroenterology, Virginia Commonwealth University's Medical College of Virginia, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA.
Gastroenterology. 2008 Jun;134(7):1842-60. doi: 10.1053/j.gastro.2008.05.021. Epub 2008 May 12.
Recent milestones in the understanding of gastric acid secretion and treatment of acid-peptic disorders include the (1) discovery of histamine H(2)-receptors and development of histamine H(2)-receptor antagonists, (2) identification of H(+)K(+)-ATPase as the parietal cell proton pump and development of proton pump inhibitors, and (3) identification of Helicobacter pylori as the major cause of duodenal ulcer and development of effective eradication regimens. This review emphasizes the importance and relevance of gastric acid secretion and its regulation in health and disease. We review the physiology and pathophysiology of acid secretion as well as evidence regarding its inhibition in the management of acid-related clinical conditions.
（1）组胺H2受体的发现及组胺H2受体拮抗剂的研发；（2）H⁺K⁺-ATP酶作为壁细胞质子泵的鉴定及质子泵抑制剂的研发；（3）幽门螺杆菌作为十二指肠溃疡主要病因的鉴定及有效根除方案的研发。本综述强调胃酸分泌及其调节在健康和疾病中的重要性及相关性。我们回顾了胃酸分泌的生理和病理生理学，以及其在酸相关性临床病症管理中抑制作用的相关证据。
