在结核病和疟疾中利用宿主的血红素加氧酶-1途径。
CO-opting the host HO-1 pathway in tuberculosis and malaria.
作者信息
Sinnis Photini, Ernst Joel D
机构信息
Department of Medical Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
出版信息
Cell Host Microbe. 2008 May 15;3(5):277-9. doi: 10.1016/j.chom.2008.04.009.
Abstract
Infection with Mycobacterium tuberculosis and Plasmodium species results in upregulation of the host heme oxygenase-1 pathway. In tuberculosis infection, this leads to upregulation of the bacterial "dormancy regulon," whereas in malaria, it enhances the efficiency with which sporozoites develop into exoerythrocytic stages. Here we discuss these findings as well as some of the interesting questions they raise.
摘要
结核分枝杆菌和疟原虫感染会导致宿主血红素加氧酶-1途径上调。在结核感染中，这会导致细菌“休眠调节子”上调，而在疟疾中，它会提高子孢子发育为细胞外期的效率。在此，我们讨论这些发现以及它们引发的一些有趣问题。
相似文献
1
CO-opting the host HO-1 pathway in tuberculosis and malaria.在结核病和疟疾中利用宿主的血红素加氧酶-1途径。
Cell Host Microbe. 2008 May 15;3(5):277-9. doi: 10.1016/j.chom.2008.04.009.
2
Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.结核分枝杆菌在巨噬细胞感染期间感知宿主来源的一氧化碳。
Cell Host Microbe. 2008 May 15;3(5):323-30. doi: 10.1016/j.chom.2008.03.007.
3
Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.血红素加氧酶-1是一种抗炎宿主因子，可促进小鼠疟原虫肝脏感染。
Cell Host Microbe. 2008 May 15;3(5):331-8. doi: 10.1016/j.chom.2008.04.003.
4
Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.血红素加氧酶-1衍生的一氧化碳诱导结核分枝杆菌休眠调节子。
J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 Apr 9.
5
Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model.伯氏疟原虫的自然传播会加重实验性合并感染模型中的慢性结核病。
PLoS One. 2012;7(10):e48110. doi: 10.1371/journal.pone.0048110. Epub 2012 Oct 26.
6
Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection.血红素加氧酶-1 介导的血红素分解代谢赋予宿主对分枝杆菌感染的抵抗力。
Infect Immun. 2013 Jul;81(7):2536-45. doi: 10.1128/IAI.00251-13. Epub 2013 Apr 29.
7
Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes.宿主血红素加氧酶-1的药理学抑制通过一种依赖于T淋巴细胞的机制在体内抑制结核分枝杆菌感染。
mBio. 2016 Oct 25;7(5):e01675-16. doi: 10.1128/mBio.01675-16.
8
Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection.血红素加氧酶-1 抑制促进 IFNγ-和 NOS2 介导的结核分枝杆菌感染控制。
Mucosal Immunol. 2021 Jan;14(1):253-266. doi: 10.1038/s41385-020-00342-x. Epub 2020 Aug 29.
9
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.血红素加氧酶-1与一氧化碳可抑制实验性脑型疟疾的发病机制。
Nat Med. 2007 Jun;13(6):703-10. doi: 10.1038/nm1586. Epub 2007 May 13.
10
Iron metabolism and the innate immune response to infection.铁代谢与先天免疫对感染的反应。
Microbes Infect. 2012 Mar;14(3):207-16. doi: 10.1016/j.micinf.2011.10.001. Epub 2011 Oct 20.
引用本文的文献
1
The emerging role of gasotransmitters in the pathogenesis of tuberculosis.气体递质在结核病发病机制中的新作用。
Nitric Oxide. 2016 Sep 30;59:28-41. doi: 10.1016/j.niox.2016.06.009. Epub 2016 Jul 4.
2
Expanding the antimalarial toolkit: Targeting host-parasite interactions.拓展抗疟工具包：靶向宿主-寄生虫相互作用
J Exp Med. 2016 Feb 8;213(2):143-53. doi: 10.1084/jem.20151677. Epub 2016 Feb 1.
3
Tuberculosis Comorbidity with Communicable and Noncommunicable Diseases.结核病与传染病和非传染病的合并症
Cold Spring Harb Perspect Med. 2015 Feb 6;5(11):a017889. doi: 10.1101/cshperspect.a017889.
4
Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice.血红素加氧酶-1 调节老龄小鼠对流感病毒感染和疫苗接种的免疫反应。
FASEB J. 2012 Jul;26(7):2911-8. doi: 10.1096/fj.11-190017. Epub 2012 Apr 6.
本文引用的文献
1
Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.血红素加氧酶-1是一种抗炎宿主因子，可促进小鼠疟原虫肝脏感染。
Cell Host Microbe. 2008 May 15;3(5):331-8. doi: 10.1016/j.chom.2008.04.003.
2
Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.结核分枝杆菌在巨噬细胞感染期间感知宿主来源的一氧化碳。
Cell Host Microbe. 2008 May 15;3(5):323-30. doi: 10.1016/j.chom.2008.03.007.
3
Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.血红素加氧酶-1衍生的一氧化碳诱导结核分枝杆菌休眠调节子。
J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 Apr 9.
4
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.血红素加氧酶-1与一氧化碳可抑制实验性脑型疟疾的发病机制。
Nat Med. 2007 Jun;13(6):703-10. doi: 10.1038/nm1586. Epub 2007 May 13.
5
6
The role of heme oxygenase-1 promoter polymorphisms in human disease.血红素加氧酶-1启动子多态性在人类疾病中的作用。
Free Radic Biol Med. 2004 Oct 15;37(8):1097-104. doi: 10.1016/j.freeradbiomed.2004.07.008.
7
Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis.两种传感器激酶参与结核分枝杆菌的低氧应答。
J Biol Chem. 2004 May 28;279(22):23082-7. doi: 10.1074/jbc.M401230200. Epub 2004 Mar 19.
8
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.一氧化氮对呼吸的抑制会诱导结核分枝杆菌的休眠程序。
J Exp Med. 2003 Sep 1;198(5):705-13. doi: 10.1084/jem.20030205.
9
Heme oxygenase-1: unleashing the protective properties of heme.血红素加氧酶-1：释放血红素的保护特性。
Trends Immunol. 2003 Aug;24(8):449-55. doi: 10.1016/s1471-4906(03)00181-9.
10
Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis.Rv3133c/dosR是一种介导结核分枝杆菌缺氧反应的转录因子。
Mol Microbiol. 2003 May;48(3):833-43. doi: 10.1046/j.1365-2958.2003.03474.x.
Zotero 插件