Sharma Bhavna, Balomajumder Chandrajeet, Roy Partha
Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247 667, Uttarakhand, India.
Food Chem Toxicol. 2008 Jul;46(7):2376-83. doi: 10.1016/j.fct.2008.03.020. Epub 2008 Mar 28.
The hypoglycemic and hypolipidemic effects of flavonoid rich extract obtained from seeds of Eugenia jambolana (EJ) was analyzed in streptozotocin induced diabetic rats. Hypoglycemic activity was assessed by reduction in fasting blood glucose (FBG) and peak blood glucose level within 60 min of glucose tolerance test (GTT) in mild and severe diabetic (MD and SD respectively) rats. Different biochemical parameters like glycogen biosynthesis, glucose homeostatic enzyme (glucose-6-phosphatase, hexokinase) activities demonstrated significant (p<0.05) improvement as compared to diabetic counter parts. Further, the flavonoids also stimulated 16% increase in insulin release in vitro from pancreatic islets. The hypolipidemic action after this extract supplementation was confirmed by significant (p<0.05) decrease in the levels of LDL (27% MD, 29% SD), triglycerides (about 35% MD, 37% SD) and increase in HDL (21% MD, 34% SD) over untreated diabetic rats. The above mentioned action of this plant extract was found to be through dual up regulation of both the peroxisome proliferators-activated receptors (PPARalpha and PPARgamma) up to about 3-4 folds (over control) and their capacity to differentiate 3T3-L1 preadipocytes. The present data suggests that the flavonoid rich extract from EJ plant has both hypoglycemic and hypolipidemic effects which can help the cure and management of diabetes.
在链脲佐菌素诱导的糖尿病大鼠中分析了从蒲桃种子中提取的富含黄酮类化合物的提取物的降血糖和降血脂作用。通过轻度和重度糖尿病（分别为MD和SD）大鼠葡萄糖耐量试验（GTT）60分钟内空腹血糖（FBG）的降低和血糖峰值水平来评估降血糖活性。与糖尿病对照组相比，糖原生物合成、葡萄糖稳态酶（葡萄糖-6-磷酸酶、己糖激酶）活性等不同生化参数显示出显著（p<0.05）改善。此外，黄酮类化合物还能在体外刺激胰岛胰岛素释放增加16%。补充该提取物后的降血脂作用通过与未治疗的糖尿病大鼠相比，低密度脂蛋白（MD降低27%，SD降低29%）、甘油三酯（MD约降低35%，SD降低37%）水平显著（p<0.05）降低以及高密度脂蛋白（MD升高21%，SD升高34%）升高得到证实。发现该植物提取物的上述作用是通过过氧化物酶体增殖物激活受体（PPARα和PPARγ）的双重上调，上调幅度高达约3至4倍（相对于对照）以及它们分化3T3-L1前脂肪细胞的能力实现的。目前的数据表明，来自蒲桃植物的富含黄酮类化合物的提取物具有降血糖和降血脂作用，有助于糖尿病的治疗和管理。
