Sharma S B, Nasir A, Prabhu K M, Murthy P S, Dev G
Department of Biochemistry, University College of Medical Sciences and GTB Hospital, Delhi 110095, India.
J Ethnopharmacol. 2003 Apr;85(2-3):201-6. doi: 10.1016/s0378-8741(02)00366-5.
The hypoglycaemic and hypolipidemic effect of ethanolic extract obtained from seeds of E. jambolana was investigated in alloxan-induced diabetic rabbits. Hypoglycaemic activity was assessed by reduction in fasting blood glucose (FBG) at 90min and also fall in peak blood glucose during glucose tolerance test (GTT) in sub-diabetic and mild diabetic (MD) rabbits, but in severe diabetic (SD) rabbits by reduction in FBG at 90min. Ethanolic extract (100mg/kg body weight) when given orally to sub-diabetic (AR) for 1 day, MD for 7 days and SD for 15 days showed significant fall in FBG at 90min (12% AR, 18.9% MD and 29% SD) and also produced 16.9% fall in peak blood glucose in AR and 21% in MD rabbits during GTT. When administered daily for 15 days to MD and SD rabbits, significant fall in FBG (41.3% MD, 31.6% SD) and glycosylated haemoglobin (GHb) levels (23.3% MD, 26.6% SD) were observed, while serum insulin level showed significant increase (32.8% MD, 26.9% SD). Liver and muscle glycogen content also increased. The ethanolic extract of seeds also exhibited significant hypolipidemic effect as evident from fall in total serum cholesterol (TC)/high density lipoprotein cholesterol (HDL-c) ratio, serum low density lipoprotein cholesterol (LDL-c) levels and decreased activity of HMG-CoA reductase. The histopathological studies of liver, pancreas and aorta in alcoholic extract treated diabetic groups revealed almost normal appearance.
研究了从紫铆树种子中提取的乙醇提取物对四氧嘧啶诱导的糖尿病兔的降血糖和降血脂作用。通过测定亚糖尿病和轻度糖尿病（MD）兔在葡萄糖耐量试验（GTT）中90分钟时空腹血糖（FBG）的降低以及峰值血糖的下降来评估降血糖活性，而对于重度糖尿病（SD）兔，则通过测定90分钟时FBG的降低来评估。当口服给予亚糖尿病（AR）兔乙醇提取物（100mg/kg体重）1天、MD兔7天、SD兔15天时，90分钟时FBG显著下降（AR兔下降12%，MD兔下降18.9%，SD兔下降29%），并且在GTT期间，AR兔的峰值血糖下降了16.9%，MD兔下降了21%。当每天给MD和SD兔给药15天时，观察到FBG显著下降（MD兔下降41.3% , SD兔下降31.6%）以及糖化血红蛋白（GHb）水平显著下降（MD兔下降23.3%，SD兔下降26.6%），而血清胰岛素水平显著升高（MD兔升高32.8%，SD兔升高26.9%）。肝脏和肌肉糖原含量也增加。种子的乙醇提取物还表现出显著的降血脂作用，总血清胆固醇（TC）/高密度脂蛋白胆固醇（HDL-c）比值下降、血清低密度脂蛋白胆固醇（LDL-c）水平下降以及HMG-CoA还原酶活性降低均证明了这一点。乙醇提取物治疗的糖尿病组肝脏、胰腺和主动脉的组织病理学研究显示外观几乎正常。
