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99mTc-环丙沙星在金黄色葡萄球菌和铜绿假单胞菌中的蓄积

Accumulation of 99mTc-ciprofloxacin in Staphylococcus aureus and Pseudomonas aeruginosa.

作者信息

Sierra J M, Rodriguez-Puig D, Soriano A, Mensa J, Piera C, Vila J

机构信息

Department of Infectious Diseases, Hospital Clinic, IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain.

出版信息

Antimicrob Agents Chemother. 2008 Jul;52(7):2691-2. doi: 10.1128/AAC.00217-08. Epub 2008 May 12.

DOI:10.1128/AAC.00217-08
PMID:18474577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2443927/
Abstract

The use of radiopharmaceuticals for the diagnosis of infection is increasing due to their ability to distinguish between septic and aseptic inflammation. The aim of this study was to analyze the intracellular accumulation of technetium-99m-ciprofloxacin in strains of Staphylococcus aureus and Pseudomonas aeruginosa harboring an overexpression of NorA and MexAB-OprM, respectively.

摘要

由于放射性药物能够区分感染性炎症和无菌性炎症，其在感染诊断中的应用正在增加。本研究的目的是分析分别携带过表达的NorA和MexAB - OprM的金黄色葡萄球菌和铜绿假单胞菌菌株中锝-99m-环丙沙星的细胞内积累情况。

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本文引用的文献

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The selection of resistance to and the mutagenicity of different fluoroquinolones in Staphylococcus aureus and Streptococcus pneumoniae.金黄色葡萄球菌和肺炎链球菌对不同氟喹诺酮类药物的耐药性选择及致突变性
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Effect of siliconized latex urinary catheters on the activity of carbapenems against Pseudomonas aeruginosa strains with defined mutations in ampC, oprD, and genes coding for efflux systems.硅化乳胶导尿管对碳青霉烯类药物针对在ampC、oprD以及编码外排系统的基因中存在特定突变的铜绿假单胞菌菌株活性的影响。
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Inability of 99mTc-ciprofloxacin scintigraphy to discriminate between septic and sterile osteoarticular diseases.99mTc-环丙沙星闪烁扫描术无法区分感染性和无菌性骨关节炎疾病。
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Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection.喹诺酮类耐药机制：靶点改变、蓄积减少及DNA回旋酶保护。
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Infecton: a 99mTc-ciprofloxacin radiopharmaceutical for the detection of bone infection.
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Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations.锝-99m标记的抗菌肽可区分细菌感染和无菌性炎症。
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