Department of Medicine Harvard Medical School Massachusetts General Hospital Fruit Street, Bulfinch 422 Boston MA 02114 USA.
Mediators Inflamm. 1992;1(5):341-5. doi: 10.1155/S0962935192000516.
Intravenous injection into rats of immune complexes (IC) prepared in 5 x antigen excess rapidly induces annular bands of vascular congestion and transmural haemorrhage producing a striped appearance of the small intestine. Indirect evidence suggested a major role for PAF in the induction of lesions. In the present study, we showed that blood and leukocyte levels of PAF were elevated in most rats injected 10 min earlier with sufficient IC to induce lesions of 3+ to 4+ intensity. There was no significant difference in the number of rats with elevated plasma levels of PAF. The possibility that changes in blood PAF levels might be mirrored at sites closer to the lesions was considered. The overall effect of PAF on the small intestine of the rats is to induce stasis of flow; the precise target of PAF in mediating this effect is unknown.
向大鼠静脉内注射用 5 倍抗原过剩制备的免疫复合物(IC),可迅速引起环状血管充血带和壁内出血,使小肠呈现条纹状外观。间接证据表明 PAF 在诱导病变中起主要作用。在本研究中,我们表明,在 10 分钟前用足以诱导 3+至 4+强度病变的足够 IC 注射的大多数大鼠中,血液和白细胞中的 PAF 水平升高。血浆 PAF 水平升高的大鼠数量没有显著差异。考虑到血液 PAF 水平的变化可能在更接近病变的部位得到反映。PAF 对大鼠小肠的总体影响是引起血流停滞;PAF 介导这种作用的确切靶标尚不清楚。