Kirkham S E, Bloch K J, Bloch M B, Perry R P, Walker W A
Dig Dis Sci. 1986 Jul;31(7):737-43. doi: 10.1007/BF01296452.
Adult male Sprague-Dawley rats injected with preformed rat anti-bovine serum albumin antibody-bovine serum albumin complexes prepared in fivefold antigen excess, developed intestinal lesions consisting of annular bands of serosal hyperemia alternating with nonhyperemic bands, causing a striped appearance. Histologically, vascular congestion and mucosal edema were observed; more severe lesions were accompanied by hemorrhage, epithelial necrosis and sloughing, and modest polymorphonuclear leukocyte infiltration. The lesions developed rapidly and were accompanied by hemoconcentration. A correlation between the dose of immune complexes injected and the intensity and extent of intestinal lesions was noted. The pathogenetic mechanism of the lesions was not determined. The similarity of the lesions to those observed in systemic anaphylaxis in the rat and experimental and clinical shock was cited. The implications of immune complex-induced enteropathy for studies of immune complex clearance by the mononuclear phagocyte system were considered.
成年雄性斯普拉格-道利大鼠注射用五倍抗原过量制备的预形成大鼠抗牛血清白蛋白抗体-牛血清白蛋白复合物后，出现肠道病变，表现为浆膜充血的环形带与非充血带交替出现，形成条纹状外观。组织学上，观察到血管充血和黏膜水肿；更严重的病变伴有出血、上皮坏死和脱落，以及适度的多形核白细胞浸润。病变发展迅速，并伴有血液浓缩。注意到注射的免疫复合物剂量与肠道病变的强度和范围之间存在相关性。病变的发病机制尚未确定。文中引用了这些病变与大鼠全身过敏反应以及实验性和临床休克中观察到的病变的相似性。还考虑了免疫复合物诱导的肠病对单核吞噬细胞系统清除免疫复合物研究的影响。
