特应性皮炎患者血小板组织胺氧化酶的病理学变化。
Pathological changes in platelet histamine oxidases in atopic eczema.
机构信息
Research Department Spezialklinik Neukirchen Neukirchen 93453 Germany.
出版信息
Mediators Inflamm. 1993;2(6):403-6. doi: 10.1155/S0962935193000560.
Increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet-rich plasma of atopic eczema (AE) patients. The diamine oxidase has almost normal cofactor levels (pyridoxal phosphate and Cu(2+)) but the cofactor levels for type B monoamine oxidase (flavin adenine dinucleotide and Fe(2+)) are lowered. The biogenic amines putrescine, cadaverine, spermidine, spermine, tyramine and serotonin in the sera, as well as dopamine and epinephrine in EDTA-plasma were found to be normal. It is unlikely, therefore, that these amines are responsible for the decreased activities of monoamine and diamine oxidase in these patients. The most likely causative factors for the inhibition of the diamine oxidase are nicotine, alcohol, food additives and other environmental chemicals, or perhaps a genetic defect of the diamine oxidase.
在特应性皮炎（AE）患者富含血小板的血浆中，升高的血浆组氨酸水平与显著降低的二胺和 B 型单胺氧化酶活性有关。二胺氧化酶几乎具有正常的辅因子水平（吡哆醛磷酸盐和 Cu(2+)），但 B 型单胺氧化酶（黄素腺嘌呤二核苷酸和 Fe(2+)）的辅因子水平降低。在血清中的生物胺腐胺、尸胺、亚精胺、精胺、酪胺和 5-羟色胺，以及 EDTA-血浆中的多巴胺和肾上腺素均正常。因此，这些胺类不太可能是导致这些患者单胺和二胺氧化酶活性降低的原因。二胺氧化酶抑制的最可能的致病因素是尼古丁、酒精、食品添加剂和其他环境化学物质，或者可能是二胺氧化酶的遗传缺陷。
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