利用离子对萃取和带安培检测的高效液相色谱法测定人血浆中的酪胺。
Measurement of tyramine in human plasma, utilising ion-pair extraction and high-performance liquid chromatography with amperometric detection.
作者信息
Causon R C, Brown M J
出版信息
J Chromatogr. 1984 Sep 14;310(1):11-7. doi: 10.1016/0378-4347(84)80063-8.
PMID:6501508
Abstract
An assay for plasma tyramine has been developed which uses ion-pair extraction, reversed-phase ion-pair high-performance liquid chromatography and amperometric detection. Tritiated tyramine is used as the internal standard. The method can measure down to 0.5 ng/ml of tyramine in 1 ml of human plasma and is thus suitable for monoamine oxidase inhibitor studies involving oral dosing with tyramine.
摘要
已开发出一种血浆酪胺测定法，该方法采用离子对萃取、反相离子对高效液相色谱法和安培检测法。用氚标记的酪胺作为内标。该方法可检测1毫升人血浆中低至0.5纳克/毫升的酪胺，因此适用于涉及口服酪胺的单胺氧化酶抑制剂研究。
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