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本文引用的文献

1

Differential regulation of cytokine and cytokine receptor genes by PAF, LTB4 and PGE2.

J Lipid Mediat. 1993 Mar-Apr;6(1-3):175-81.

2

Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis--suppressive effect of TA-383 on interleukin 6 production.

Int J Immunopharmacol. 1993 May;15(4):515-9. doi: 10.1016/0192-0561(93)90066-8.

3

Enhanced expression of interleukin 6 in rat and murine arthritis models.

Int J Immunopharmacol. 1993 May;15(4):469-76.

4

Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro.

Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):65-8.

5

Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages.

Yao Xue Xue Bao. 1993;28(10):721-7.

6

Leflunomide inhibits cytokine-induced DNA synthesis of rabbit synovial cells in culture.

Zhongguo Yao Li Xue Bao. 1994 May;15(3):223-6.

7

Production of hybridoma growth factor by human monocytes.

Eur J Immunol. 1987 Oct;17(10):1411-6. doi: 10.1002/eji.1830171004.

8

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.

Eur J Immunol. 1988 Nov;18(11):1797-801. doi: 10.1002/eji.1830181122.

9

The interrelation between TNF, IL-6, and PAF secretion induced by LPS in an in vivo and in vitro murine model.

Lymphokine Cytokine Res. 1991 Apr;10(1-2):127-31.

10

Interleukin-6 and its relation to inflammation and disease.

Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 2):S60-5. doi: 10.1016/0090-1229(92)90042-m.

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三唑并哒嗪对体外培养的鼠脾细胞和兔滑膜细胞白细胞介素-6产生的影响。

Effects of triazolodiazepine on the production of interleukin-6 from murine spleen cells and rabbit synovial cells in vitro.

机构信息

Department of Immunology School of Basic Medicine Second Military Medical University Shanghai 200433 China.

出版信息

Mediators Inflamm. 1995;4(2):130-2. doi: 10.1155/S0962935195000226.

DOI:10.1155/S0962935195000226

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2365624/

Abstract

Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, acute phase anaphylactic reaction, and haematopoiesis. Lipopolysaccharide (6-24 mug/ml) significantly induced IL-6 release from murine spleen cells. In cultured rabbit synovial cells interleukin-1 (IL-1, 1-10 U/ml) induced IL-6 production in a concentration-dependent manner. Triazolodiazepine (Tri) is a hetrazepine platelet-activating factor antagonist. In this study we found that Tri (0.1-10 mumol/l) exerted strong inhibitory effects on LPS stimulated IL-6 production in murine spleen cells. Kinetic studies showed that the inhibition of IL-6 release was time-independent. In rabbit synovial cells Tri also reduced IL-6 release induced by IL-1 and tumour necrosis factor. Inhibition of cytokine production by Tri may partially explain its wide and strong anti-inflammatory effects.

摘要

白细胞介素-6（IL-6）是一种多功能细胞因子，可调节免疫反应、急性过敏反应和造血。脂多糖（6-24ug/ml）可显著诱导鼠脾细胞释放白细胞介素-6。在培养的兔滑膜细胞中，白细胞介素-1（IL-1，1-10U/ml）以浓度依赖性方式诱导白细胞介素-6的产生。三唑并[1,5-a]嘧啶（Tri）是一种杂环嗪血小板激活因子拮抗剂。在这项研究中，我们发现 Tri（0.1-10umol/L）对 LPS 刺激的鼠脾细胞白细胞介素-6的产生具有强烈的抑制作用。动力学研究表明，IL-6 释放的抑制与时间无关。Tri 还可减少 IL-1 和肿瘤坏死因子诱导的兔滑膜细胞白细胞介素-6的释放。Tri 对细胞因子产生的抑制作用可能部分解释了其广泛而强大的抗炎作用。