Rola-Pleszczynski M, Thivierge M, Gagnon N, Lacasse C, Stankova J
Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.
J Lipid Mediat. 1993 Mar-Apr;6(1-3):175-81.
Immune and inflammatory responses involve a whole array of cells and cell products which interact and mutually regulate each other. Many of these interactions are mediated by cytokines acting through specific receptors. Furthermore, lipid mediators such as PAF and the arachidonic acid metabolites LTB4 and PGE2 are known to affect several of the mechanisms involved in the regulation of the immune and inflammatory responses. In this paper, we review recent data from our laboratory illustrating the differential regulation of IL-6 and TNF alpha production and IL-2 receptor alpha and beta expression by these lipid mediators. We show that the regulation of these genes is both transcriptional and post-transcriptional, and that LT and PG can also be involved as second messengers in these regulatory processes.
免疫和炎症反应涉及一系列相互作用和相互调节的细胞及细胞产物。其中许多相互作用是由细胞因子通过特定受体介导的。此外，已知脂质介质如血小板活化因子（PAF）以及花生四烯酸代谢产物白三烯B4（LTB4）和前列腺素E2（PGE2）会影响免疫和炎症反应调节过程中的多种机制。在本文中，我们回顾了来自我们实验室的最新数据，这些数据阐明了这些脂质介质对白细胞介素-6（IL-6）和肿瘤坏死因子α（TNFα）产生以及白细胞介素-2受体α和β表达的差异调节作用。我们表明，这些基因的调节既有转录水平的，也有转录后水平的，并且白三烯（LT）和前列腺素（PG）也可作为第二信使参与这些调节过程。
