Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M
Division of Immunology, Osaka University, Japan.
Eur J Immunol. 1988 Nov;18(11):1797-801. doi: 10.1002/eji.1830181122.
High levels of interleukin 6 (IL 6/B cell stimulatory factor-2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL 6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL 6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL 6. The data indicate that IL 6 is generated constitutively in RA and its overproduction may explain the local as well as the generalized symptoms of RA, since IL 6 can function as B cell growth and differentiation factor as well as hepatocyte-stimulating factor.
在活动期类风湿关节炎（RA）患者关节的滑液中检测到高水平的白细胞介素6（IL-6/ B细胞刺激因子-2）。新鲜分离的滑液中的细胞组成性表达IL-6 mRNA。通过关节活检获得的滑膜组织在体外也被发现能产生IL-6。免疫组织化学分析表明，滑膜组织中的CD2 + T细胞以及CD20 +母细胞样B细胞产生IL-6。数据表明，IL-6在RA中持续产生，其过量产生可能解释了RA的局部以及全身症状，因为IL-6可以作为B细胞生长和分化因子以及肝细胞刺激因子发挥作用。
