急性和慢性荨麻疹患者的血液嗜酸性粒细胞和血清嗜酸性粒细胞阳离子蛋白。
Blood eosinophils and serum eosinophil cationic protein in patients with acute and chronic urticaria.
机构信息
Cattedra di Medicina Interna II Istituto di Medicina Interna e Geriatria Italy.
出版信息
Mediators Inflamm. 1996;5(2):113-5. doi: 10.1155/S0962935196000191.
We have analysed the relationship of blood eosinophil count and serum eosinophil cationic protein (ECP) levels in patients with acute and chronic idiopathic urticaria. The ECP levels and eosinophil counts were measured in the peripheral blood of 15 patients with acute urticaria, 25 with chronic idiopathic urticaria and 10 normal healthy subjects. Blood eosinophil counts and serum ECP levels increased in all patients with acute urticaria. Concerning patients affected by chronic urticaria, taking into account the recrudescence of the disease at the moment of taking the blood sample, only symptomatic patients showed increased eosinophil blood values whereas serum ECP levels were increased both in symptomatic and asymptomatic patients. Furthermore, serum ECP levels in chronic urticaria did not correlate with the peripheral eosinophil counts, as they did in acute urticaria. The results of the present study indicate that eosinophils may play a role in the inflammatory mechanisms in patients with acute and chronic urticaria showing a positive correlation between serum ECP levels and disease activity.
我们分析了急性和慢性特发性荨麻疹患者的血嗜酸性粒细胞计数和血清嗜酸性粒细胞阳离子蛋白（ECP）水平的关系。在 15 例急性荨麻疹患者、25 例慢性特发性荨麻疹患者和 10 例正常健康受试者的外周血中测量了 ECP 水平和嗜酸性粒细胞计数。所有急性荨麻疹患者的血嗜酸性粒细胞计数和血清 ECP 水平均升高。对于患有慢性荨麻疹的患者，考虑到在采血时疾病的复发，只有症状性患者表现出血液嗜酸性粒细胞值升高，而血清 ECP 水平在症状性和无症状性患者中均升高。此外，慢性荨麻疹患者的血清 ECP 水平与外周嗜酸性粒细胞计数无关，而急性荨麻疹患者则呈正相关。本研究结果表明，嗜酸性粒细胞可能在急性和慢性特发性荨麻疹患者的炎症机制中发挥作用，血清 ECP 水平与疾病活动度呈正相关。
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