含羟基二硫代氨基甲酸盐对顺铂诱导的肾功能障碍的预防作用
The prevention of cisplatin-induced renal dysfunction by hydroxyl-containing dithiocarbamates.
作者信息
Reznik L V, Myazina E M, Shakchmatova E I, Gambaryan S P, Brovtsyn V K, Natochin Y V, Jones M M
机构信息
Laboratory of Renal Physiology and Water-Electrolyte Metabolism, Sechenov Institute of Evolutionary Physiology and Biochemistry, USSR Academy of Sciences, Leningrad.
出版信息
Br J Cancer. 1991 Feb;63(2):234-6. doi: 10.1038/bjc.1991.55.
Two hydroxyl containing dithiocarbamates, sodium N-methyl-D-glucamine dithiocarbamate (NaG) and sodium dihydroxyethyl dithiocarbamate (NaY) have been examined as agents for the control of the renal dysfunction in rats given cisplatin. Of these, NaG was found to be the more effective in controlling such renal dysfunction when administered at 1 and 3 h after 5 mg cisplatin kg-1, i.p. Renal function was examined 5 days after the administration of cisplatin by measurement of serum and urinary levels of creatinine and urea, creatinine clearance, serum and urinary levels of Na+, K+, Mg2+, Ca2+, as well as the concentrations of these ions in the renal medulla and cortex. Treatment of rats given cisplatin with NaG at 1 and 3 h post cisplatin resulted in indices of renal function which were not significantly different from those of animals which had received no cisplatin. The sole difference was found to be a slight increase in renal cortical Na+ concentration.
已对两种含羟基的二硫代氨基甲酸盐，即N-甲基-D-葡糖胺二硫代氨基甲酸钠（NaG）和二羟乙基二硫代氨基甲酸钠（NaY）作为控制顺铂给药大鼠肾功能障碍药物进行了研究。其中，在腹腔注射5mg顺铂/kg后1小时和3小时给予NaG时，发现其在控制此类肾功能障碍方面更有效。在顺铂给药5天后，通过测量血清和尿液中的肌酐和尿素水平、肌酐清除率、血清和尿液中的Na+、K+、Mg2+、Ca2+水平以及这些离子在肾髓质和皮质中的浓度来检查肾功能。在顺铂给药后1小时和3小时用NaG治疗顺铂给药大鼠，其肾功能指标与未接受顺铂的动物无显著差异。唯一的差异是肾皮质Na+浓度略有增加。
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