Shinobu L A, Jones S G, Jones M M
Arch Toxicol. 1983 Nov;54(3):235-42. doi: 10.1007/BF01239207.
Mice with chronic cadmium intoxication were given low levels (0.6 mm/kg) of several dithiocarbamates (parent compounds: dihydroxyethylamine, iminodiacetic acid, methylhydroxyethylamine and sarcosine) in an attempt to reduce the cadmium present in the liver and kidney. Comparing the results with those obtained with the less polar sodium diethyldithiocarbamate (NaDDTC), only ammonium di(hydroxyethyl)dithiocarbamate (NH4DHE-DTC) possessed a similar ability to reduce kidney cadmium levels. Under the experimental conditions employed, the reduction obtained with NH4DHE-DTC was less than that effected by a comparable dose of NaDDTC. A subsequent dose-dependence study showed, however, that sodium di(hydroxyethyl)dithiocarbamate (NaDHE-DTC) is quite effective at higher dosage levels (up to 5.5 mmoles/kg) where substantial reductions in both kidney (89% mobilization) and liver (38% mobilization) stores of cadmium were observed. High doses of the NaDHE-DTC are well tolerated as the LD50 of this compound in mice is greater than 19.8 mmoles/kg.
给慢性镉中毒的小鼠投喂低剂量（0.6 毫摩尔/千克）的几种二硫代氨基甲酸盐（母体化合物：二羟乙胺、亚氨基二乙酸、甲基羟乙胺和肌氨酸），试图降低肝脏和肾脏中的镉含量。将结果与用极性较小的二乙基二硫代氨基甲酸钠（NaDDTC）得到的结果进行比较，只有二（羟乙基）二硫代氨基甲酸铵（NH4DHE-DTC）具有类似降低肾脏镉含量的能力。在所采用的实验条件下，NH4DHE-DTC 所实现的镉含量降低程度小于同等剂量的 NaDDTC 所产生的降低程度。然而，随后的剂量依赖性研究表明，二（羟乙基）二硫代氨基甲酸钠（NaDHE-DTC）在较高剂量水平（高达 5.5 毫摩尔/千克）时相当有效，此时观察到肾脏（89%的镉动员）和肝脏（38%的镉动员）中的镉储存量大幅降低。高剂量的 NaDHE-DTC 耐受性良好，因为该化合物在小鼠中的半数致死量大于 19.8 毫摩尔/千克。
