通过铑催化烯酮的还原α-酰化直接合成1,3-二酮
Direct synthesis of 1,3-diketones by Rh-catalyzed reductive alpha-acylation of enones.
作者信息
Sato Kazuyuki, Yamazoe Satoshi, Yamamoto Rie, Ohata Shizuka, Tarui Atsushi, Omote Masaaki, Kumadaki Itsumaro, Ando Akira
机构信息
Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
出版信息
Org Lett. 2008 Jun 19;10(12):2405-8. doi: 10.1021/ol800660y. Epub 2008 May 14.
PMID:18476711
Abstract
1,3-Diketones were synthesized from alpha,beta-unsaturated ketones by treatment with acid chlorides and Et(2)Zn in the presence of RhCl(PPh(3))3. This is a very simple and extremely chemoselective reaction to give the adduct at the alpha-position of alpha,beta-unsaturated ketones.
摘要
通过在三（三苯基膦）氯化铑存在下用酰氯和二乙基锌处理α,β-不饱和酮来合成1,3-二酮。这是一个非常简单且具有极高化学选择性的反应，能在α,β-不饱和酮的α位生成加合物。
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