Ikeda Etsuko, Tsuji Takashi
Faculty of Industrial Science and Technology Tokyo University of Science, Department of Biological Science and Technology, Noda, Chiba 278-8510, Japan.
Expert Opin Biol Ther. 2008 Jun;8(6):735-44. doi: 10.1517/14712598.8.6.735.
The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs that can replace organs lost or damaged due to disease, injury or aging. Dental regenerative medicine has made the most progress and is the most useful model for the consideration of strategies in future organ replacement therapies.
This review describes strategies that have been pursued to date and experiments currently being conducted to bioengineer teeth in anticipation of the production of fully functional organs.
To realize the practical application of 'bioengineered tooth' transplantation therapy, four major hurdles must be overcome. The present status of the hurdles to this therapy are described and discussed in this review.
RESULTS/CONCLUSION: The bioengineering techniques developed for tooth regeneration will in the future make substantial contributions to the ability to grow primordial organs in vitro and also to grow fully functioning organs, such as the liver, kidney and heart.
再生治疗的最终目标是开发出功能完备的生物工程器官，以替代因疾病、损伤或衰老而丧失或受损的器官。牙科再生医学取得了最大进展，是未来器官替代疗法策略考量中最有用的模型。
本综述描述了迄今为止为生物工程牙齿所采用的策略以及目前正在进行的相关实验，以期生产出功能完备的器官。
为实现“生物工程牙齿”移植治疗的实际应用，必须克服四个主要障碍。本综述对该治疗障碍的现状进行了描述和讨论。
结果/结论：为牙齿再生开发的生物工程技术未来将对体外培育原始器官以及培育如肝脏、肾脏和心脏等功能完备的器官做出重大贡献。
