Soudi Armin, Yazdanian Mohsen, Ranjbar Reza, Tebyanian Hamid, Yazdanian Alireza, Tahmasebi Elahe, Keshvad Ali, Seifalian Alexander
Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Veterinary, Science and Research Branch, Islamic Azad University, Tehran, Iran.
EXCLI J. 2021 Feb 22;20:454-489. doi: 10.17179/excli2021-3335. eCollection 2021.
Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly contribute to the state-of-the-art clinical strategies for SC-based alveolar bone regeneration. The donor cells and immune cells play a prominent role in determining the clinical success of MSCs therapy. In line with the promising future that stem cell therapy has shown for tissue engineering applications, dental stem cells have also attracted the attention of the relevant researchers in recent years. The current literature review aims to survey the variety and extension of SC-application in tissue-regenerative dentistry. In this regard, the relevant English written literature was searched using keywords: "tissue engineering", "stem cells", "dental stem cells", and "dentistry strategies". According to the available database, SCs application has become increasingly widespread because of its accessibility, plasticity, and high proliferative ability. Among the growing recognized niches and tissues containing higher SCs, dental tissues are evidenced to be rich sources of MSCs. According to the literature, dental SCs are mostly present in the dental pulp, periodontal ligament, and dental follicle tissues. In this regard, the present review has described the recent findings on the potential of dental stem cells to be used in tissue regeneration.
近年来，人们越来越关注基于干细胞（SC）的疗法在再生治疗中的潜在优势。间充质干/基质细胞（MSCs）现在被认为是组织替代疗法和组织工程的优秀候选者。自体MSCs对基于SC的牙槽骨再生的先进临床策略做出了重要贡献。供体细胞和免疫细胞在决定MSCs治疗的临床成功方面起着重要作用。与干细胞疗法在组织工程应用中所展现的光明前景相一致，近年来牙源性干细胞也吸引了相关研究人员的关注。当前的文献综述旨在调查SC在组织再生牙科中的应用种类和范围。在这方面，使用关键词“组织工程”“干细胞”“牙源性干细胞”和“牙科策略”搜索了相关的英文文献。根据现有数据库，由于其易获取性、可塑性和高增殖能力，SCs的应用越来越广泛。在越来越被认可的含有较高SCs的微环境和组织中，牙组织被证明是MSCs的丰富来源。根据文献，牙源性SCs大多存在于牙髓、牙周膜和牙囊组织中。在这方面，本综述描述了牙源性干细胞用于组织再生潜力的最新研究结果。
