Karaca Semsettin, Seyhan Muammer, Senol Mustafa, Harputluoglu M Muhip, Ozcan Atilla
Department of Dermatology, School of Medicine, Inonu University, Malatya, Turkey.
Int J Dermatol. 2008 Jun;47(6):615-7. doi: 10.1111/j.1365-4632.2008.03667.x.
Helicobacter pylori (H. pylori) has been suggested to be associated with recurrent aphthous stomatitis (RAS) as well as many other diseases.
We conducted a prospective study on a total of 23 patients with RAS to investigate the relationship between H. pylori and RAS as well as the effect of eradication therapy on the recurrence. All patients underwent endoscopic examination and gastric biopsy. The biopsy materials were examined histopathologically whether they contained H. pylori or not. The density of H. pylori was also noted. The patients with H. pylori infection were followed up for up to 1 year after starting the eradication therapy.
Gastric mucosal H. pylori colonization was + in 39%, ++ in 39%, +++ in 9%, and - in 13% of the patients, respectively. There were statistically significant decreases in the recurrence rate and amelioration time of RAS by eradication therapy. There were no significant correlations among the intensity of H. pylori with the recurrence rate, number, diameter, and amelioration time of the lesions in 1-year follow-up.
We concluded that eradication of H. pylori may have reducing effects on the recurrence and amelioration period of the RAS.
幽门螺杆菌（H. pylori）被认为与复发性阿弗他口炎（RAS）以及许多其他疾病有关。
我们对总共23例RAS患者进行了一项前瞻性研究，以调查幽门螺杆菌与RAS之间的关系以及根除治疗对复发的影响。所有患者均接受了内镜检查和胃活检。对活检材料进行组织病理学检查，以确定是否含有幽门螺杆菌。同时记录幽门螺杆菌的密度。幽门螺杆菌感染患者在开始根除治疗后随访长达1年。
胃黏膜幽门螺杆菌定植情况在患者中分别为：+占39%，++占39%，+++占9%，-占13%。根除治疗使RAS的复发率和缓解时间有统计学意义的降低。在1年随访中，幽门螺杆菌感染强度与病变的复发率、数量、直径和缓解时间之间无显著相关性。
我们得出结论，根除幽门螺杆菌可能对RAS的复发和缓解期有降低作用。
