Khandpur Sujay, Malhotra Amit K, Bhatia Vidhyut, Gupta Subandhu, Sharma Vinod K, Mishra Rakesh, Arora Narendra K
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Int J Dermatol. 2008 Jun;47(6):618-21. doi: 10.1111/j.1365-4632.2008.03475.x.
Ayurvedic medicines are known to contain arsenic and concentrations up to toxic levels have been reported in certain formulations. However, clinical disease due to arsenic containing ayurvedic medicines has rarely been reported. We seek to highlight the existence of toxic levels of arsenic in certain ayurvedic preparations that can produce serious systemic manifestations.
An 11-year-old girl developed manifestations of arsenical keratosis (punctuate palmoplantar keratoderma and leucomelanoderma) and non-cirrhotic portal hypertension, 6 months and 18 months respectively after intake of ayurvedic medications, prescribed for epilepsy. The eight ayurvedic preparations consumed by the patient and her serum levels were analyzed for arsenic content.
Arsenic content of ayurvedic medicines ranged from 5 mg/L to 248 mg/L. The serum arsenic level was 202.20 microg/L (normal < 60 microg/L). Skin manifestations improved after the discontinuation of ayurvedic medications.
Ayurvedic medications should be consumed under strict guidance and supervision of qualified practitioners to prevent such catastrophies.
已知阿育吠陀药物含有砷，并且在某些制剂中已报告其浓度高达有毒水平。然而，由含砷阿育吠陀药物引起的临床疾病鲜有报道。我们旨在强调某些阿育吠陀制剂中存在有毒水平的砷，这些砷可产生严重的全身表现。
一名11岁女孩在分别摄入用于治疗癫痫的阿育吠陀药物6个月和18个月后，出现了砷角化病（点状掌跖角化病和白瘢黑变病）及非肝硬化性门静脉高压的表现。对患者服用的8种阿育吠陀制剂及其血清水平进行了砷含量分析。
阿育吠陀药物的砷含量范围为5毫克/升至248毫克/升。血清砷水平为202.20微克/升（正常<60微克/升）。停用阿育吠陀药物后皮肤表现有所改善。
阿育吠陀药物应在合格从业者的严格指导和监督下服用，以防止此类灾难发生。
